Dynamic immunogenicity after primary and booster inactivated SARS-CoV-2 vaccination in people living with HIV: A longitudinal observational study

作者全名："Lu, Ting; Chen, Zhiwei; Cao, Yu; Ao, Ling; Li, Zisheng; Gu, Xiaoyi; Ren, Xingqian; Wang, Yixuan; Zhang, Gaoli; Xiang, Dejuan; Chen, Min; Cai, Dachuan; Hu, Peng; Zhang, Dazhi; Peng, Mingli; Shi, Xiaofeng; Ren, Hong"

作者地址："[Lu, Ting; Ao, Ling; Wang, Yixuan; Zhang, Gaoli; Xiang, Dejuan; Chen, Min; Hu, Peng; Peng, Mingli; Ren, Hong] Chongqing Med Univ, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis, Minist Educ,Affiliated Hosp 2, Chongqing, Peoples R China; [Lu, Ting; Cao, Yu; Li, Zisheng; Gu, Xiaoyi; Ren, Xingqian] Peoples Hosp Tongliang Dist, Chongqing, Peoples R China; [Chen, Zhiwei; Cai, Dachuan; Hu, Peng; Zhang, Dazhi; Shi, Xiaofeng; Ren, Hong] Chongqing Med Univ, Dept Infect Dis, Affiliated Hosp 2, Chongqing, Peoples R China; [Zhang, Dazhi; Peng, Mingli; Shi, Xiaofeng; Ren, Hong] Chongqing Med Univ, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis, Chinese Minist Educ,Affiliated Hosp 2, Chongqing 400010, Peoples R China"

通信作者："Zhang, DZ; Peng, ML; Shi, XF; Ren, H (通讯作者)，Chongqing Med Univ, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis, Chinese Minist Educ,Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000989594000039

JCR分区：Q1

影响因子：6.8

年份：2023

卷号：95

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：HIV; immunogenicity; inactivated vaccines; memory B cells; SARS-CoV-2

摘要："People living with HIV (PLWH) have poor outcomes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); vaccination reduces the associated mortality. The humoral immune response dynamics after booster inactivated vaccinations in PLWH remain unclear. In this longitudinal observational study, 100 PLWH after primary inactivated SARS-CoV-2 vaccination were consecutively recruited and followed up. After booster vaccination (BV), neutralizing antibodies (NAbs) were detected at 1 month from all the PLWH, and the titer increased sixfold compared to that associated with the primary vaccination (PV), similar to that in healthy controls after BV. The NAbs titer declined over time after BV, but remained higher at 6 months than after PV. The NAbs response was elevated after BV with CD4 count <200 cells/mu L, it was the poorest among the different CD4 cell count subgroups. Similar results were observed for anti-RBD-IgG responses. Moreover, RBD-specific MBCs were significantly elevated after BV in PLWH. No serious AEs were observed after BV in PLWH. In conclusion, booster inactivated SARS-CoV-2 vaccination is well tolerated and can elicit robust and durable humoral responses in PLWH. PLWH may benefit from a third dose of the inactivated vaccine."

基金机构：National Science and Technology Major Project of China

基金资助正文：National Science and Technology Major Project of China