The potential of Chinese medicines in the treatment of hyperuricemia

作者全名："Tang, Jiaqi; Gao, Hongyan; Xu, Yanqiu; Chen, Jingru; Wu, Bin"

作者地址："[Tang, Jiaqi; Xu, Yanqiu; Wu, Bin] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China; [Tang, Jiaqi; Xu, Yanqiu; Wu, Bin] Chongqing Hosp Tradit Chinese Med, Dept Rheumatol, Chongqing 400021, Peoples R China; [Gao, Hongyan] Chongqing Key Lab Tradit Chinese Med Prevent & Tre, R China, Chongqing 400021, Peoples R China; [Chen, Jingru] Hunan Univ Tradit Chinese Med, Changsha 410208, Peoples R China; [Wu, Bin] Chongqing Hosp Tradit Chinese Med, Dept Rheumatol, 6 Pan Xi Qi Zhi Rd, Chongqing 400021, Peoples R China"

通信作者："Wu, B (通讯作者)，Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China.; Wu, B (通讯作者)，Chongqing Hosp Tradit Chinese Med, Dept Rheumatol, Chongqing 400021, Peoples R China.; Wu, B (通讯作者)，Chongqing Hosp Tradit Chinese Med, Dept Rheumatol, 6 Pan Xi Qi Zhi Rd, Chongqing 400021, Peoples R China."

来源：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000989966900002

JCR分区：Q3

影响因子：1.7

年份：2023

卷号：15

期号：4

开始页：2291

结束页：2303

文献类型：Review

关键词：Hyperuricemia; uric acid lowering; xanthine oxidase; uric acid metabolism transporter; Chinese medicines

摘要："The annual incidence of gout is increasing along with lifestyle and dietary changes. Accumulation of urate crystals in joints and tissues when the amount of uric acid exceeds its saturation concentration causes acute inflammation that leads to gout. Reducing the serum uric acid concentration is the key to treating gout. Allopurinol, febuxostat, benzbromarone, and other drugs are effective, but side effects of treatment such as toxicity and recurrence after drug withdrawal cannot be ignored. Recent studies have found that many Chinese medicines are effective and safe, provide durable efficacy, and are associated with low recurrence rates. This article reviews recent investigations of Chinese medicines for lowering uric acid, including components such as berberine, luteolin, and others; single medicines such as Smilax glabra Roxb., Reynoutria japonica Houtt., and Plantago asiatica L.; and compounds such as Wuling Powder and Compound Tufuling Granules. Mechanisms of lowering uric acid, including inhibiting uric acid production and promoting uric acid excretion are discussed. Clinical studies and basic research are reviewed."

基金机构："Chongqing Science and Technology Commission [cstc2019jscx-dxwtBX0023, cstc2018jxj- 1130084]"

基金资助正文："The study was supported by the Chongqing Science and Technology Commission (Grant No. cstc2019jscx-dxwtBX0023, cstc2018jxj- 1130084) ."