Factors influencing USgHIFU ablation for adenomyosis with NPVR >= 50%

作者全名："Yu, Jing-Wen; Yang, Mei-Jie; Jiang, Li; Su, Xue-Yao; Chen, Jin-Yun"

作者地址："[Yu, Jing-Wen; Jiang, Li; Chen, Jin-Yun] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Yang, Mei-Jie] Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China; [Su, Xue-Yao] Chongqing Med Univ, Coll Publ Hlth, Chongqing, Peoples R China; [Chen, Jin-Yun] Chongqing Med Univ, Ultrasound Ablat Ctr, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Chen, JY (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000990266000001

JCR分区：Q2

影响因子：3

年份：2023

卷号：40

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：High-intensity focused ultrasound (HIFU); adenomyosis; non-perfused; volume ratio (NPVR); safety; magnetic resonance imaging (MRI)

摘要："Objective To investigate the influencing factors of ultrasound-guided HIFU (USgHIFU) ablation for adenomyosis with a non-perfused volume ratio (NPVR)>= 50%. Methods A total of 299 patients with adenomyosis who underwent USgHIFU ablation were enrolled. Quantitative signal intensity (SI) analysis was performed on T2WI and dynamic enhancement type. The energy efficiency factor (EEF) was defined as the ultrasound energy delivered for ablating 1 mm(3) of tissue. NPVR >= 50% was used as the criterion for technical success. Adverse effects and complications were recorded. Logistic regression analyses of variables were conducted to identify the factors affecting NPVR >= 50%. Results The median NPVR was 53.5% (34.7%). There were 159 cases in the NPVR >= 50% group and 140 cases in the NPVR < 50% group. The EEF in NPVR < 50.0% group was significantly higher than that in NPVR >= 50% group (p < 0.05). The incidence of intraoperative adverse effects and postoperative adverse events in the NPVR < 50% group were higher than those in the NPVR >= 50% group (p < 0.05 for both). Logistic regression analysis showed that abdominal wall thickness, SI difference on T2WI between adenomyosis and rectus abdominis, and enhancement type on T1WI were protective factors for NPVR >= 50% (p < 0.05), while the history of childbirth was an independent risk factor (p < 0.001). Conclusions Compared with NPVR < 50%, NPVR >= 50% did not increase the intraprocedural and postprocedural adverse reactions. The possibility of NPVR >= 50% was higher in patients with thinner abdominal walls, showed slight enhancement of adenomyosis on T1WI, with a history of childbirth, or in whom the SI difference on T2WI between adenomyosis and rectus abdominis was more minor."

基金机构：Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0514]; Young Project of Science and Technology Research Program of Chongqing Education Commission of China [KJQN202200478]

基金资助正文：This study was supported by the Natural Science Foundation of Chongqing [grant number cstc2021jcyj-msxmX0514] and the Young Project of Science and Technology Research Program of Chongqing Education Commission of China [No. KJQN202200478].