Development of a Microfluidic Formatted Ultrasound-Controlled Monodisperse Lipid Vesicles' Hydrogel Dressing Combined with Ultrasound for Transdermal Drug Delivery System

作者全名："He, Chengdian; He, Xiong; Zhang, Yi; Han, Xiaofeng; Yang, Yujun; Shen, Yong; Wang, Teng; Wu, Qing; Yang, Yukun; Xu, Wei; Bai, Jin; Wang, Zhenyu"

作者地址："[He, Chengdian; He, Xiong; Zhang, Yi; Shen, Yong; Wang, Teng; Wu, Qing; Yang, Yukun; Bai, Jin; Wang, Zhenyu] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; [He, Chengdian; He, Xiong; Zhang, Yi; Shen, Yong; Wang, Teng; Wu, Qing; Yang, Yukun; Bai, Jin; Wang, Zhenyu] Chongqing Med Univ, Coll Biomed Engn, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China; [Han, Xiaofeng; Xu, Wei] Chongqing First Peoples Hosp, Dept Dermatol, Chongqing 400011, Peoples R China; [Han, Xiaofeng; Xu, Wei] Chongqing Tradit Chinese Med Hosp, Chongqing 400011, Peoples R China; [Yang, Yukun] Chongqing Med Univ, Minist Educ, Dept Lab Med, Key Lab Lab Med Diagnost,Chongqing Med Lab Microfl, Chongqing 400016, Peoples R China; [Yang, Yukun] Chongqing Med Univ, SPRi Engn Res Ctr, Chongqing 400016, Peoples R China"

通信作者："Bai, J; Wang, ZY (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China.; Bai, J; Wang, ZY (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China.; Xu, W (通讯作者)，Chongqing First Peoples Hosp, Dept Dermatol, Chongqing 400011, Peoples R China.; Xu, W (通讯作者)，Chongqing Tradit Chinese Med Hosp, Chongqing 400011, Peoples R China."

来源：MACROMOLECULAR BIOSCIENCE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000992103000001

JCR分区：Q1

影响因子：4.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：hydrogel dressings; lipid vesicles; microfluidic; transdermal drug delivery systems; ultrasound-controlled

摘要："Transdermal drug delivery system (TDDS) has attracted much attention in the pharmaceutical technology area. However, the current methods are difficult to ensure penetration efficiency, controllability, and safety in the dermis, so its widespread clinical use has been limited. This work proposes an ultrasound-controlled monodisperse lipid vesicles (U-CMLVs) hydrogel dressing, which combines with ultrasound to form TDDS. Using microfluidic technology, prepare size controllable U-CMLVs with high drug encapsulation efficiency and quantitative encapsulation of ultrasonic response materials, and even uniform mix them with hydrogel to prepare the required thickness of dressings. The high encapsulation efficiency can ensure sufficient dosage of the drugs and further realize the control of ultrasonic response through quantitative encapsulation of ultrasound-responsive materials. Using high frequency (5 MHz, 0.4 W cm(-2)) and low frequency (60 kHz, 1 W cm(-2)) ultrasound to control the movement and rupture of U-CMLVs, the contents not only penetrate the stratum corneum into the epidermis but also break through the bottleneck of penetration efficiency, and deep into the dermis. These findings provide the groundwork for deep, controllable, efficient, and safe drug delivery through TDDS and lay a foundation for further expanding its application."

基金机构："National Natural Science Foundation of China [81501617]; Special Funds for Technology Innovation and Application Development of Chongqing, China [cstc2020jscx-msxmX0064]; Science Foundation Project of Chongqing Education Commission [KJQN202000420]"

基金资助正文："Acknowledgements This work was supported by the National Natural Science Foundation of China (grants no. 81501617), the Special Funds for Technology Innovation and Application Development of Chongqing, China (grants no. cstc2020jscx-msxmX0064), and the Science Foundation Project of Chongqing Education Commission (grants no. KJQN202000420)."