"A novel prognostic model based on pretreatment serum albumin and ECOG PS for primary CNS lymphoma: an international, multi-center study"

作者全名："Wei, Li; Gao, Yuting; Prochazka, Katharina Theresa; Liu, Rongqiu; Wang, Liang; Liu, Boyang; He, Yingzhi; Bertero, Luca; Pellerino, Alessia; Cassoni, Paola; Tamagnone, Luca; Deutsch, Alexander J.; Zhan, Huien; Lai, Jing; Kim, Seok Jin; You, Hua"

作者地址："[Wei, Li] Chongqing Populat & Family Planning Sci & Technol, NHC Key Lab Birth Defects & Reprod Hlth, Chongqing, Peoples R China; [Wei, Li] Chongqing Hosp Tradit Chinese Med, Chongqing, Peoples R China; [Gao, Yuting; Liu, Rongqiu; You, Hua] Chongqing Med Univ, Dept Pediat Hematol & Oncol, Lab Excellence Syst Biomed Pediat Oncol, Childrens Hosp, 136 Zhongshan Second Rd, Chongqing 401122, Peoples R China; [Gao, Yuting; Liu, Rongqiu; You, Hua] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,Childre, 136 Zhongshan Second Rd, Chongqing 401122, Peoples R China; [Prochazka, Katharina Theresa; Deutsch, Alexander J.] Med Univ Graz, Clin Dept Hematol, Auenbruggerpl 38, A-8010 Graz, Austria; [Wang, Liang] Capital Med Univ, Beijing Tongren Hosp, Dept Hematol, Beijing 100730, Peoples R China; [Liu, Boyang] Southern Med Univ, Educ Minist China Diag & Treatment Cerebrovasc Di, Guangdong Prov Key Lab Brain Funct Repair & Regen, Zhujiang Hosp,Dept Neurosurg Ctr,Neurosurg Inst G, Guangzhou 510282, Peoples R China; [He, Yingzhi] Southern Med Univ, Dept Hematol, ZhuJiang Hosp, Guangzhou, Peoples R China; [Bertero, Luca; Cassoni, Paola] Univ Turin, Dept Med Sci, Pathol Unit, Via Santena 7, I-10126 Turin, Italy; [Pellerino, Alessia] Univ Turin, Dept Neurooncol, Via Cherasco 15, I-10126 Turin, Italy; [Pellerino, Alessia] City Hlth & Sci Hosp, Via Cherasco 15, I-10126 Turin, Italy; [Tamagnone, Luca] Univ Cattolica Sacro Cuore, Dept Life Sci & Publ Hlth, I-10068 Rome, Italy; [Tamagnone, Luca] Fdn Policlin Univ A Gemelli IRCCS, I-10068 Rome, Italy; [Zhan, Huien; Lai, Jing] Jinan Univ, Affiliated Hosp 1, Dept Hematol, Guangzhou, Peoples R China; [Kim, Seok Jin] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematol Oncol,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea"

通信作者："You, H (通讯作者)，Chongqing Med Univ, Dept Pediat Hematol & Oncol, Lab Excellence Syst Biomed Pediat Oncol, Childrens Hosp, 136 Zhongshan Second Rd, Chongqing 401122, Peoples R China.; You, H (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,Childre, 136 Zhongshan Second Rd, Chongqing 401122, Peoples R China.; Kim, SJ (通讯作者)，Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematol Oncol,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea."

来源：JOURNAL OF NEURO-ONCOLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000993342400001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：163

期号：2

开始页：301

结束页：311

文献类型：Article

关键词：Primary central nervous system lymphoma; Albumin; Eastern Cooperative Oncology Group performance status (ECOG PS); Prognostic model; Multi-center study

摘要："BackgroundSerum albumin has been demonstrated as prognostic parameter in non-Hodgkin lymphoma (NHL). Primary central nervous system lymphoma (PCNSL) is a rare extranodal NHL with highly aggressive behavior. In this study, we aimed at creating a novel prognostic model for PCNSL based on serum albumin levels.MethodsWe compared several commonly used laboratory nutritional parameters for predicting the survival of PCNSL patients using overall survival (OS) for outcome analysis and receiver operating characteristic curve analysis to determine the optimal cut-off values. Parameters associated with OS were evaluated by univariate and multivariate analyses. Independent prognostic parameters for OS were selected for risk stratification, including albumin <= 4.1 g/dL, ECOG PS > 1, and LLR > 166.8, which were associated with shorter OS; albumin > 4.1 g/dL, ECOG PS 0-1 and LLR <= 166.8, which were associated with longer OS, and five-fold cross-validation was used for evaluating predictive accuracy of identified prognostic model.ResultsBy univariate analysis, age, ECOG PS, MSKCC score, Lactate dehydrogenase-to-lymphocyte ratio (LLR), total protein, albumin, hemoglobin, and albumin to globulin ratio (AGR) resulted statistically associated with the OS of PCNSL. By multivariate analysis, albumin <= 4.1 g/dL, ECOG PS > 1, and LLR > 166.8 were confirmed to be significant predictors of inferior OS. We explored several PCNSL prognostic models based on albumin, ECOG PS and LLR with 1 point assigned to each parameter. Eventually, a novel and effective PCNSL prognostic model based on albumin and ECOG PS successfully classified patients into three risk groups with 5-year survival rates of 47.5%, 36.9%, and 11.9%, respectively.ConclusionsThe novel two-factor prognostic model based on albumin and ECOG PS we propose represents a simple but significant prognostic tool for assessing newly diagnosed patients with PCNSL."

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