Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis

作者全名："Jing, Xu; Zhuyuan, Wen; Aijun, Chen; Jianxia, Xiong; Kun, Huang; Ping, Wang"

作者地址："[Jing, Xu; Zhuyuan, Wen; Aijun, Chen; Jianxia, Xiong; Kun, Huang; Ping, Wang] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China; [Zhuyuan, Wen] Chongqing Med Univ, Coll Pediat, Chongqing, Peoples R China"

通信作者："Ping, W (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000993654800001

JCR分区：Q1

影响因子：3.1

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：psoriasis; chronic kidney disease (CKD); end-stage renal disease (ESRD); renal injury; meta-analysis

摘要："Background and objective: Previous studies have shown that patients with psoriasis are at higher risk of developing chronic kidney disease (CKD) and end-stage renal disease (ESRD) compared with general population; however, data on the differences in the occurrence of CKD and ESRD between patients with psoriasis and non-psoriatic controls are limited and inconsistent. The aim of this study was to carry out a comparison of the probability of suffering CKD and ESRD in patients with or without psoriasis by conducting a meta-analysis of cohort studies.Methods: Cohort studies on PubMed, Web of Science, Embase and Cochrane Library by March, 2023 were searched for. The studies were screened according to pre-established inclusion criteria. Hazard ratios (HRs) and a 95% confidence intervals (CIs) for the renal outcomes among patients with psoriasis were calculated using the random-effect, generic inverse variance method. Subgroup analysis was related to the severity of psoriasis.Results: A total of seven retrospective cohort studies were included, including 738,104 psoriasis patients and 3,443,438 non-psoriasis subjects, published from 2013 to 2020. Compared to controls without psoriasis, patients with psoriasis had an increased risk of CKD and ESRD, with pooled hazard ratios of 1.65 (95% CI, 1.29-2.12) and 1.37 (95% CI, 1.14-1.64), respectively. Besides, the incidence of CKD and ESRD is positively correlated with the severity of psoriasis.Conclusion: This study showed that compared to patients without psoriasis, patients with psoriasis, especially those with severe psoriasis, had a significantly increased risk of developing CKD and ESRD. Considering the limitations of this meta-analysis, more high-quality and well-designed studies are needed in the future to validate our findings."

基金机构：National Natural Science Foundation of China [NSFC 82103733]

基金资助正文："Funding This research was funded by National Natural Science Foundation of China, grant number NSFC 82103733."