Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/ overweight

作者全名："Zhu, Qian; Zhang, Yingzhi; Kang, Juan; Chen, Zhiwei; Peng, Mingli; Chen, Min; Zhang, Gaoli; Xiang, Dejuan; Xiao, Shuang; Li, Hu; Mei, Ying; Yang, Jie; Qi, Xiaoya; Cai, Dachuan; Ren, Hong"

作者地址："[Zhu, Qian; Zhang, Yingzhi; Kang, Juan; Chen, Zhiwei; Peng, Mingli; Chen, Min; Zhang, Gaoli; Xiang, Dejuan; Xiao, Shuang; Li, Hu; Cai, Dachuan; Ren, Hong] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400061, Peoples R China; [Mei, Ying; Yang, Jie; Qi, Xiaoya] Chongqing Med Univ, Hlth Management Ctr, Affiliated Hosp 2, Chongqing 400061, Peoples R China; [Ren, Hong] 288 Tianwen Ave, Chongqing, Peoples R China"

通信作者："Cai, DC; Ren, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400061, Peoples R China.; Ren, H (通讯作者)，288 Tianwen Ave, Chongqing, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000995834200001

JCR分区：Q1

影响因子：6.9

年份：2023

卷号：10

期号：2

开始页：608

结束页：617

文献类型：Article

关键词：COVID-19; Immune response; Inactivated vaccine; Obesity; Overweight

摘要："Inactivated COVID-19 vaccines have been widely used to vaccinate the Chinese population. However, limited literature exists to explore the effect of obesity on the humoral and cellular immune response to these vaccines. In this study, 132 high BMI (Body mass index) (obesity and overweight, BMI > 24 kg/m2) and 82 normal BMI (BMI < 24 kg/m2) participants were enrolled. Adverse events (AEs), Spike receptor-binding domain IgG antibody (anti-RBD-IgG), neutralizing antibodies (NAbs), and specific B-cell and T-cell responses were evaluated 21-105 days after full-course inactivated COVID-19 vaccination. The overall incidence of AEs was similar in individuals with and without obesity/overweight. No serious vaccine-related AEs occurred. Individuals with obesity/overweight had a reduced seropositivity rate of NAbs compared to those with normal BMI. Anti-RBD-IgG and NAbs titers in the high BMI group were significantly lower than those in the normal BMI group. The frequencies of RBD-specific memory B cells (MBCs) and the numbers of spike-specific TNF-a+ spot-forming cells (SFCs) in individuals with obesity/overweight were reduced compared with those noted in individuals without obesity/overweight. A similar trend of weakened humoral responses was also observed in individuals with central obesity. Our study results suggested that inactivated COVID-19 vac-cines were safe and well tolerated but induced poor humoral and cellular immune responses in Chinese individuals with obesity/overweight.(c) 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/)."

基金机构："National Science and Technology Major Project of China [2017ZX10202203-007, 2017ZX10202203-008, 2018ZX10302206-003]; National Natural Science Foundation of China [81772198]; Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0389]; General Project of Chongqing Natural Science Foundation [cstc2020jcyj-msxmX0015]; pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine: hepatic fibrosis"

基金资助正文："This work was supported by the National Science and Technology Major Project of China (No. 2017ZX10202203-007, No. 2017ZX10202203-008, and No. 2018ZX10302206-003) and a pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine: hepatic fibrosis. We also acknowledge the support of the National Natural Science Foundation of China (No. 81772198), and the Natural Science Foundation of Chongqing, China (No. cstc2020jcyj-msxmX0389), General Project of Chongqing Natural Science Foundation (No. cstc2020jcyj-msxmX0015)."