Clinical application of a modified predeposit autologous red blood cell apheresis in multistage spinal fusion: a single-center retrospective study

作者全名："Xu, Xiao-Ping; Que, Wen-Jun; Yu, Ze-Bo; Shen, Jie-Liang; Hu, Zhen-Ming; Yang, Xiao-Liang; Hao, Jie"

作者地址："[Xu, Xiao-Ping; Shen, Jie-Liang; Hu, Zhen-Ming; Hao, Jie] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China; [Que, Wen-Jun; Yu, Ze-Bo; Yang, Xiao-Liang] Chongqing Med Univ, Dept Blood Transfus, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Hao, J (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China.; Yang, XL (通讯作者)，Chongqing Med Univ, Dept Blood Transfus, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000995904400001

JCR分区：Q1

影响因子：3.1

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：pre-deposit autologous RBC apheresis; multistage spinal fusion; length of stay; transfusion cost; post-operative infection

摘要："PurposeThis study aimed to evaluate the efficacy and safety of predeposit autologous RBC apheresis (PARA) in patients undergoing multilevel spinal fusion surgery. MethodsA total of 112 patients from January 2020 to June 2022 were divided into two groups according to PARA: the PARA group (n = 51) and the control group (n = 61). The baseline characteristics of the patients, outcomes, transfusion cost, hospitalization cost, length of stay, complications, and changes in hemoglobin and hematocrit levels between the two groups were compared. ResultsThe baseline characteristics were similar in both groups. No significant differences were found in functional outcomes, including VAS score (p = 0.159), ODI score (p = 0.214), JOA score (p = 0.752), and SF-36 score (p = 0.188) between the PARA and control groups. The amount and rate of intraoperative and perioperative allogeneic RBC transfusion were significantly higher in the control group than in the PARA group (p < 0.001). The postoperative (9.04 +/- 3.21 vs. 11.05 +/- 3.84, p = 0.004) and total length of stay (15.78 +/- 3.79 vs. 17.36 +/- 4.08, p = 0.038) in the PARA group were significantly lower than those in the control group, respectively. Despite no difference in hospitalization cost (p = 0.737), the total blood transfusion cost in the PARA group was significantly lower, compared with the control group (p < 0.001). For safety evaluation, there were no significant differences in Hb and Hct levels between the two groups at admission, on postoperative day 1, and postoperative day 3, respectively (p > 0.05). Moreover, the number of postoperative infections in the PARA group was significantly lower than that in the control group (p = 0.038). ConclusionPARA was a novel, safe, and highly efficient technique for mass autologous blood preparation in a quite short preparation time. This method could significantly reduce the amount of allogeneic blood transfusion and length of stay, which could provide a theoretical basis for following clinical practice about the technique."

基金机构："Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau), Chongqing, China [2021MSXM007, 2021MSXM027]; Medicine Seed Fund of the First Affiliated Hospital of Chongqing Medical University [2020-232]"

基金资助正文："This study was funded by Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau), Chongqing, China (2021MSXM007 to X-LY) and (2021MSXM027 to JH) and the Medicine Seed Fund of the First Affiliated Hospital of Chongqing Medical University (2020-232) to X-LY."