CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice

作者全名："Chen, Mengyue; Zhang, Yang; Zeng, Shu; Li, Danyang; You, Mengyue; Zhang, Mingyang; Wang, Zhenyu; Wei, Li; Chen, Yaxi; Ruan, Xiong Z."

作者地址："[Chen, Mengyue; Zhang, Yang; Zeng, Shu; Li, Danyang; You, Mengyue; Zhang, Mingyang; Wang, Zhenyu; Wei, Li; Chen, Yaxi; Ruan, Xiong Z.] Chongqing Med Univ, Ctr Lipid Res, Chongqing 400016, Peoples R China; [Chen, Mengyue; Zhang, Yang; Zeng, Shu; Li, Danyang; You, Mengyue; Zhang, Mingyang; Wang, Zhenyu; Wei, Li; Chen, Yaxi; Ruan, Xiong Z.] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Chongqing Key Lab Metabol Lipid &, Chongqing 400016, Peoples R China; [Ruan, Xiong Z.] UCL, Univ Coll London Med Sch, Ctr Nephrol, John Moorhead Res Lab, Royal Free Campus, London NW3 2PF, England"

通信作者："Chen, YX; Ruan, XZ (通讯作者)，Chongqing Med Univ, Ctr Lipid Res, Chongqing 400016, Peoples R China.; Chen, YX; Ruan, XZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Chongqing Key Lab Metabol Lipid &, Chongqing 400016, Peoples R China.; Ruan, XZ (通讯作者)，UCL, Univ Coll London Med Sch, Ctr Nephrol, John Moorhead Res Lab, Royal Free Campus, London NW3 2PF, England."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:000996426800001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：26

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："The mammalian circadian clock and glucose metabolism are highly intercon-nected, and disruption of this coupling is associated with multiple negative health outcomes. Liver is the major source of endogenous glucose production and liver clock is one of the most vital peripheral clock systems. We demonstrate that fatty acid translocase (CD36) is expressed rhythmically in mouse liver and autono-mously modulates the diurnal oscillations of liver clock and glucose homeostasis. CD36 knockout in hepatocytes inhibits the relay of insulin signaling and provokes FoxO1 nuclear shuttling, consequently increasing Per1 nuclear expression. More-over, FoxO1 can activate the central clock gene Per1 at the transcriptional level. These changes lead to a disrupted clock oscillation and behavioral rhythm. Our study first reveal that CD36 is a key regulator of the circadian oscillator and its deficiency may cause liver clock disruption, which aggravates the imbalance of glucose homeostasis and contribute to augmentation and progression of meta-bolic disease."

基金机构："National Natural Science Foundation of China [32030054, 82170586]; Chongqing Research Program of Basic Research and Frontier Technology [cstc2020jcyj-zdxmX0007]; Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University; 111 Project [D20028]; Program for Youth Innovation in Future Medicine, Chongqing Medical University"

基金资助正文："This work was supported by the National Natural Science Foundation of China (32030054, 82170586); the Chongqing Research Program of Basic Research and Frontier Technology (cstc2020jcyj-zdxmX0007); Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University; the 111 Project (No. D20028); Program for Youth Innovation in Future Medicine, Chongqing Medical University."