Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction

作者全名："Liu, Ruimin; Han, Yinying; Huang, Chenglong; Hou, Mengqian; Cheng, Rui; Wang, Shujin; Li, Xi; Tian, Jie"

作者地址："[Liu, Ruimin; Tian, Jie] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Cardiol,Key Lab Child Dev and Disorders,Minis, Chongqing 400032, Peoples R China; [Liu, Ruimin; Han, Yinying; Hou, Mengqian; Cheng, Rui; Wang, Shujin; Li, Xi] Chongqing Med Univ, Biol Sci Inst, Chongqing 400032, Peoples R China; [Huang, Chenglong] Chongqing Med Univ, Univ Town Hosp, Dept Clin Lab, Chongqing 400032, Peoples R China"

通信作者："Tian, J (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Cardiol,Key Lab Child Dev and Disorders,Minis, Chongqing 400032, Peoples R China.; Wang, SJ; Li, X (通讯作者)，Chongqing Med Univ, Biol Sci Inst, Chongqing 400032, Peoples R China."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:000996462200001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：26

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Chemerin, an adipocyte-secreted protein, has been recently suggested to be linked to metabolic syndrome and cardiac function in obese and diabetes mellitus. This study aimed to investigate the potential roles of adipokine chemerin on high fat-induced cardiac dysfunction. Chemerin (Rarres2) knockout mice, which were fed with either a normal diet or a high-fat diet for 20 weeks, were employed to observe whether adipokine chemerin affected lipid metabolism, inflammation, and cardiac function. Firstly, we found normal metabolic substrate inflexibility and cardiac function in Rarres2(-/-) mice with a normal diet. Notably, in a high-fat diet, Rarres2(-/-) mice showed lipotoxicity, insulin resistance, and inflammation, thus causing metabolic substrate inflexibility and cardiac dysfunction. Furthermore, by using in vitro model of lipid-overload cardiomyocytes, we found chemerin supplementation reversed the lipid-induced abnormalities above. Here-in, in the presence of obesity, adipocyte-derived chemerin might function as an endogenous cardioprotective factor against obese-related cardiomyopathy."

基金机构："National Key R&D Program of China [2018YFA0800401]; National Natural Science Foundation of China [81770861, 82070899, 82011530460, 81974030, 8210033375]; Natural sciences foundation of Chongqing [CSTB2022NSCQ-MSX0827, 2022NSCQ-MSX0643]; National Clinical Research Center for Child Health and Disorders [NCRCCHD-2021-KP-01]; Chongqing Municipal Education Commission [KJQN202100410, W0046]; CQMU Program for Youth Innovation in Future Medicine; [KJQN202200445]"

基金资助正文："This study was sponsored by the National Key R & D Program of China (No. 2018YFA0800401 to Xi Li); National Natural Science Foundation of China (No. 81770861, 82070899 and 82011530460 to Xi Li, 81974030 to Jie Tian, 8210033375 to Shujin Wang); Natural sciences foundation of Chongqing (No. CSTB2022NSCQ-MSX0827 to Jie Tian, 2022NSCQ-MSX0643 to Shujin Wang); Key Grant from the National Clinical Research Center for Child Health and Disorders (Grant No. NCRCCHD-2021-KP-01 to Jie Tian). Scientific and Technological Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202200445, KJQN202100410 to Shujin Wang); CQMU Program for Youth Innovation in Future Medicine(W0046)."