Nanoemulsions of Hydroxysafflor Yellow A for Enhancing Physicochemical and In Vivo Performance

作者全名："Zhang, Yingjie; Zhong, Cailing; Wang, Qiong; Zhang, Jingqing; Zhao, Hua; Huang, Yuru; Zhao, Dezhang; Yang, Junqing"

作者地址："[Zhang, Yingjie; Zhong, Cailing; Wang, Qiong; Zhang, Jingqing; Yang, Junqing] Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China; [Zhang, Yingjie; Zhong, Cailing; Wang, Qiong; Zhang, Jingqing; Zhao, Hua; Huang, Yuru; Zhao, Dezhang] Chongqing Med Univ, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China"

通信作者："Yang, JQ (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ESI学科分类：CHEMISTRY

WOS号：WOS:000996973100001

JCR分区：Q1

影响因子：4.9

年份：2023

卷号：24

期号：10

开始页：　

结束页：　

文献类型：Article

关键词：hydroxysafflor yellow A; oral administration; nanoparticle; cerebral ischemia-reperfusion injury

摘要："Stroke was always a disease that threatened human life and health worldwide. We reported the synthesis of a new type of hyaluronic acid-modified multi-walled carbon nanotube. Then, we produced hydroxysafflor yellow A-hydroxypropyl- beta-cyclodextrin phospholipid complex water-in-oil nanoemulsion with hyaluronic acid-modified multi-walled carbon nanotubes and chitosan (HC@HMC) for oral treatment of an ischemic stroke. We measured the intestinal absorption and pharmacokinetics of HC@HMC in rats. We found that the intestinal absorption and the pharmacokinetic behavior of HC@HMC was superior to that of HYA. We measured intracerebral concentrations after oral administration of HC@HMC and found that more HYA crossed the blood-brain barrier (BBB) in mice. Finally, we evaluated the efficacy of HC@HMC in middle cerebral artery occlusion/reperfusion (MCAO/R)-injured mice. In MCAO/R mice, oral administration of HC@HMC demonstrated significant protection against cerebral ischemia-reperfusion injury (CIRI). Furthermore, we found HC@HMC may exert a protective effect on cerebral ischemia-reperfusion injury through the COX2/PGD2/DPs pathway. These results suggest that oral administration of HC@HMC may be a potential therapeutic strategy for the treatment of stroke."

基金机构："China Postdoctoral Science Foundation [2019m663451]; Chongqing Science and Technology Committee; Chongqing Education Committee [cqmudstd202216, 2022NSCQ-LZX0044]; CQMU Program for Youth Innovation in Future Medicine [W0153]; Foundation for Distinguished Professor of Chongqing Medical University"

基金资助正文："This research is supported by grants from China Postdoctoral Science Foundation (2019m663451), Chongqing Science and Technology Committee and Chongqing Education Committee (2022NSCQ-LZX0044), Chongqing Education Committee (cqmudstd202216), CQMU Program for Youth Innovation in Future Medicine (W0153), Foundation for Distinguished Professor of Chongqing Medical University."