Inversion of spatio-temporal distribution heat flux and reconstruction of transient temperature field of three-layered skin tissue during hyperthermia

作者全名："Liu, Li; Liu, Chuang; Zhu, Qiaomiao; Li, Yanhao"

作者地址："[Liu, Li; Liu, Chuang; Zhu, Qiaomiao; Li, Yanhao] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China"

通信作者："Li, YH (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China."

来源：JOURNAL OF THERMAL BIOLOGY

ESI学科分类：PLANT & ANIMAL SCIENCE

WOS号：WOS:000998968600001

JCR分区：Q1

影响因子：2.9

年份：2023

卷号：114

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Hyperthermia; Multiple boundary heat fluxes; Multivariable prediction model; Simultaneous optimization inversion

摘要："Hyperthermia (for example, high-intensity focused ultrasound, laser, radio-frequency) of cancerous cells from in vitro to in vivo requires accurately obtaining the heat distribution induced by external heating into the threelayered skin tissue. Obtaining the boundary heat flux into the three-layered skin tissue is a necessary condition to realize the measurement of tissue heat distribution. Considering the complexity of multiple boundary heat fluxes in spatio-temporal distribution, this study proposes an inversion scheme to predict the spatio-temporal distribution of multiple boundary heat fluxes into the three-layered skin tissue. In the inversion scheme, a multivariable prediction model is established to solve the spatio-temporal coupling problem between the inversed boundary heat flux and measurement temperature information. Furthermore, based on the dependence between the predicted temperature and inversed boundary heat flux, the inversion system is constructed to realize the simultaneous optimization inversion of multiple boundary heat fluxes in spatio-temporal distribution. To examine the feasibility and effectiveness of inversion scheme, numerical experiments are carried out to discuss the influence of future time steps and measurement errors on the inversion results of boundary heat flux. In addition, the transient temperature field of three-layered skin tissue is reconstructed by inversed boundary heat flux, which could provide an economical, effective, and non-invasive solution for the measurement of thermal field of three-layered skin tissue during hyperthermia."

基金机构：National Natural Science Foundation of China [12204078]; science and technology research plan project of Chongqing Municipal Education Commission [KJQN202100466]

基金资助正文："Funding sources This work is supported by the National Natural Science Foundation of China (No. 12204078) , science and technology research plan project of Chongqing Municipal Education Commission (No. KJQN202100466) ."