Focused ultrasound-mediated small-molecule delivery to potentiate immune checkpoint blockade in solid tumors

作者全名："Wu, Qiuyu; Xia, Yuanhang; Xiong, Xiaohe; Duan, Xinxing; Pang, Xiaoxiao; Zhang, Fugui; Tang, Song; Su, Junlei; Wen, Shuqiong; Mei, Li; Cannon, Richard D.; Ji, Ping; Ou, Zhanpeng"

作者地址："[Wu, Qiuyu; Xia, Yuanhang; Xiong, Xiaohe; Pang, Xiaoxiao; Tang, Song; Su, Junlei; Wen, Shuqiong; Ji, Ping; Ou, Zhanpeng] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Wu, Qiuyu; Xia, Yuanhang; Xiong, Xiaohe; Pang, Xiaoxiao; Tang, Song; Su, Junlei; Wen, Shuqiong; Ji, Ping; Ou, Zhanpeng] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Duan, Xinxing] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Pang, Xiaoxiao; Zhang, Fugui; Ji, Ping; Ou, Zhanpeng] Chongqing Med Univ, Dept Oral & Maxillofacial Surg, Stomatol Hosp, Chongqing, Peoples R China; [Mei, Li; Cannon, Richard D.] Univ Otago, Sir John Walsh Res Inst, Fac Dent, Dept Oral Sci, Dunedin, New Zealand"

通信作者："Ji, P; Ou, ZP (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China.; Ji, P; Ou, ZP (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China.; Ji, P; Ou, ZP (通讯作者)，Chongqing Med Univ, Dept Oral & Maxillofacial Surg, Stomatol Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000999281400001

JCR分区：Q1

影响因子：4.4

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：focused ultrasound; small-molecule delivery systems; microbubbles; nanoparticles; immune checkpoint blockade; solid tumors

摘要："In the last decade, immune checkpoint blockade (ICB) has revolutionized the standard of treatment for solid tumors. Despite success in several immunogenic tumor types evidenced by improved survival, ICB remains largely unresponsive, especially in ""cold tumors"" with poor lymphocyte infiltration. In addition, side effects such as immune-related adverse events (irAEs) are also obstacles for the clinical translation of ICB. Recent studies have shown that focused ultrasound (FUS), a non-invasive technology proven to be effective and safe for tumor treatment in clinical settings, could boost the therapeutic effect of ICB while alleviating the potential side effects. Most importantly, the application of FUS to ultrasound-sensitive small particles, such as microbubbles (MBs) or nanoparticles (NPs), allows for precise delivery and release of genetic materials, catalysts and chemotherapeutic agents to tumor sites, thus enhancing the anti-tumor effects of ICB while minimizing toxicity. In this review, we provide an updated overview of the progress made in recent years concerning ICB therapy assisted by FUS-controlled small-molecule delivery systems. We highlight the value of different FUS-augmented small-molecules delivery systems to ICB and describe the synergetic effects and underlying mechanisms of these combination strategies. Furthermore, we discuss the limitations of the current strategies and the possible ways that FUS-mediated small-molecule delivery systems could boost novel personalized ICB treatments for solid tumors."

基金机构："National Natural Science Foundation of China [31871464, 82071115]"

基金资助正文：Funding This study was supported by grants from the National Natural Science Foundation of China (31871464 and 82071115).