Melatonin ameliorates sleep-wake disturbances and autism-like behaviors in the Ctnnd2 knock out mouse model of autism spectrum disorders

作者全名："Xu, Man; Wang, Luyi; Wang, Yan; Deng, Jing; Wang, Xiaoya; Wang, Feifei; Pan, Sen; Zhao, Yu; Liao, Ailing; Wang, Xiaoqing; Chen, Di; Shen, Jingjing; Yang, Feng; Li, Yingbo; Wang, Shali"

作者地址："[Xu, Man; Wang, Luyi; Wang, Yan; Deng, Jing; Wang, Xiaoya; Wang, Feifei; Pan, Sen; Zhao, Yu; Liao, Ailing; Wang, Xiaoqing; Chen, Di; Shen, Jingjing; Li, Yingbo; Wang, Shali] Chongqing Med Univ, Inst Neurosci, Sch Basic Med Sci, Dept Physiol, Chongqing, Peoples R China; [Xu, Man] Chongqing Univ, Dept Pediat, Fuling Hosp, Chongqing, Peoples R China; [Wang, Luyi] Chongqing Univ, Dept Nucl Med, Fuling Hosp, Chongqing, Peoples R China; [Deng, Jing] Army Med Univ, Xinqiao Hosp, Dept Neurosurg, Chongqing, Peoples R China; [Wang, Xiaoya] North Sichuan Med Coll, Dept Pathol, Affiliated Hosp, Sichuan, Peoples R China; [Pan, Sen] Chongqing Univ, Dept Urol, Fuling Hosp, Chongqing, Peoples R China; [Liao, Ailing] NHC Key Lab Birth Defects & Reprod Hlth, Chongqing Populat & Family Planning Sci & Technol, Chongqing, Peoples R China; [Yang, Feng] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [Yang, Feng] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China; [Li, Yingbo; Wang, Shali] Chongqing Med Univ, Inst Neurosci, Sch Basic Med Sci, Dept Physiol, Chongqing, Peoples R China"

通信作者："Li, YB; Wang, SL (通讯作者)，Chongqing Med Univ, Inst Neurosci, Sch Basic Med Sci, Dept Physiol, Chongqing, Peoples R China."

来源：GENES BRAIN AND BEHAVIOR

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000999969400001

JCR分区：Q2

影响因子：2.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：autism spectrum disorder; Ctnnd2; melatonin; mice; sleep-wake disorders

摘要："Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by atypical patterns of social interaction and communication, as well as restrictive and repetitive behaviors. In addition, patients with ASD often presents with sleep disturbances. Delta (delta) catenin protein 2 (CTNND2) encodes delta-catenin protein, a neuron-specific catenin implicated in many complex neuropsychiatric diseases. Our previous study demonstrated that the deletion of Ctnnd2 in mice led to autism-like behaviors. However, to our knowledge, no study has investigated the effects of Ctnnd2 deletion on sleep in mice. In this study, we investigated whether the knockout (KO) of exon 2 of the Ctnnd2 gene could induce sleep-wake disorders in mice and identified the effects of oral melatonin (MT) supplementation on Ctnnd2 KO mice. Our results demonstrated that the Ctnnd2 KO mice exhibited ASD-like behaviors and sleep-wake disorders that were partially attenuated by MT supplementation. Overall, our current study is the first to identify that knockdown of Ctnnd2 gene could induce sleep-wake disorders in mice and suggests that treatment of sleep-wake disturbances by MT may benefit to autism-like behaviors causing by Ctnnd2 gene deletion."

基金机构："Chongqing Science and Technology Committee, Basic Research and Frontier Exploration [cstc2018jcyjA1470]"

基金资助正文："ACKNOWLEDGMENTS The authors acknowledge the help from Department of Physiology of the Third Military Medical University. This work was supported by the Chongqing Science and Technology Committee, Basic Research and Frontier Exploration (no. cstc2018jcyjA1470)."