High risk of non-cancer mortality in bladder cancer patients: evidence from SEER-Medicaid

作者全名："Wang, Shunde; Ge, Chengguo"

作者地址："[Wang, Shunde] ChenJiaqiao Hosp ShaPingba Dist Chongqing City, Dept Urol, Chongqing 401331, Peoples R China; [Ge, Chengguo] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, 76 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Ge, CG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000999982400004

JCR分区：Q3

影响因子：2.7

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：Bladder cancer; Standardized mortality ratio; Non-cancer cause of death; Competing risk analysis; SEER

摘要："PurposeThe objective of this study was to investigate non-cancer causes of death and associated risk factors after bladder cancer (BC) diagnosis.MethodsEligible BC patients were obtained from the SEER database. SEER*Stat software 8.3.9.2 was used to calculate the standardized mortality ratios (SMRs). The proportions of different non-cancer cause of death were calculated and analyzed in different follow-up periods. Multivariate competing risk model was used to analyze the risk factors for death of BC and non-cancer diseases.ResultsIn total, 240,954 BC patients were included and 106,092 patients experienced death, with 37,205 (35.07%), 13,208 (12.45%) and 55,679 (52.48%) patients experienced BC, other cancer and non-cancer disease-related deaths, respectively. Overall SMR for BC patients who died from non-cancer diseases was 2.42 (95% CI [2.40-2.44]). Cardiovascular diseases were the most common non-cancer cause of death, followed by respiratory diseases, diabetes mellitus, and infectious diseases. Multivariate competing risk analysis identified the following high-risk factors for non-cancer mortality: age > 60 years, male, whites, in situ stage, pathological type of transitional cell carcinoma, not receiving treatment (including surgery, chemotherapy, or radiation), and widowed.ConclusionsCardiovascular diseases are the leading non-cancer cause of death in BC patients, followed by respiratory disease, diabetes mellitus and infectious diseases. Physicians should pay attention to the risk of death from these non-cancer diseases. Also, physicians should encourage patients to engage in more proactive self-surveillance and follow up."

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