Surveillance of prognostic risk factors in patients with SCCB using artificial intelligence: a retrospective study

作者全名："Zhanghuang, Chenghao; Zhang, Zhaoxia; Wang, Jinkui; Yao, Zhigang; Ji, Fengming; Wu, Chengchuang; Ma, Jing; Yang, Zhen; Xie, Yucheng; Tang, Haoyu; Yan, Bing"

作者地址："[Zhanghuang, Chenghao; Yao, Zhigang; Ji, Fengming; Wu, Chengchuang; Tang, Haoyu; Yan, Bing] Kunming Med Univ, Kunming Childrens Hosp, Childrens Hosp, Yunnan Prov Clin Res Ctr Childrens Hlth & Dis,Dept, 288 Qianxing Rd, Kunming 650228, Yunnan, Peoples R China; [Zhanghuang, Chenghao; Zhang, Zhaoxia; Wang, Jinkui] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Urol,China Int Sci & Technol Cooperat Base Ch, Chongqing, Peoples R China; [Zhanghuang, Chenghao; Yan, Bing] Kunming Med Univ, Childrens Hosp, Kunming Childrens Hosp, Yunnan Key Lab Childrens Major Dis Res,Yunnan Prov, Kunming, Peoples R China; [Ma, Jing] Kunming Med Univ, Childrens Hosp, Kunming Childrens Hosp, Dept Otolaryngol, Kunming, Peoples R China; [Zhanghuang, Chenghao; Yang, Zhen] Kunming Med Univ, Childrens Hosp, Kunming Childrens Hosp, Yunnan Children Solid Tumor Treatment Ctr,Dept Onc, Kunming, Peoples R China; [Xie, Yucheng] Kunming Med Univ, Childrens Hosp, Kunming Childrens Hosp, Dept Pathol, Kunming, Peoples R China"

通信作者："Yan, B (通讯作者)，Kunming Med Univ, Kunming Childrens Hosp, Childrens Hosp, Yunnan Prov Clin Res Ctr Childrens Hlth & Dis,Dept, 288 Qianxing Rd, Kunming 650228, Yunnan, Peoples R China.; Yan, B (通讯作者)，Kunming Med Univ, Childrens Hosp, Kunming Childrens Hosp, Yunnan Key Lab Childrens Major Dis Res,Yunnan Prov, Kunming, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:001000101800042

JCR分区：Q1

影响因子：3.8

年份：2023

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Small cell carcinoma of the bladder (SCCB) is a rare urological tumor. The prognosis of SCCB is abysmal. Therefore, this study aimed to construct nomograms that predict overall survival (OS) and cancer-specific survival (CSS) in SCCB patients. Information on patients diagnosed with SCCB during 2004-2018 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox regression models analyzed Independent risk factors affecting patients' OS and CSS. Nomograms predicting the OS and CSS were constructed based on the multivariate Cox regression model results. The calibration curve verified the accuracy and reliability of the nomograms, the concordance index (C-index), and the area under the curve (AUC). Decision curve analysis (DCA) assessed the potential clinical value. 975 patients were included in the training set (N = 687) and the validation set (N = 288). Multivariate COX regression models showed that age, marital status, AJCC stage, T stage, M stage, surgical approach, chemotherapy, tumor size, and lung metastasis were independent risk factors affecting the patients' OS. However, distant lymph node metastasis instead AJCC stage is the independent risk factor affecting the CSS in the patients. We successfully constructed nomograms that predict the OS and CSS for SCCB patients. The C index of the training set and the validation set of the OS were 0.747 (95% CI 0.725-0.769) and 0.765 (95% CI 0.736-0.794), respectively. The C index of the CSS were 0.749 (95% CI 0.710-0.773) and 0.786 (95% CI 0.755-0.817), respectively, indicating that the predictive models of the nomograms have excellent discriminative power. The calibration curve and the AUC also show good accuracy and discrimination of the nomograms. To sum up, We established nomograms to predict the OS and CSS of SCCB patients. The nomograms have undergone internal cross-validation and show good accuracy and reliability. The DCA shows that the nomograms have an excellent clinical value that can help doctors make clinical-assisted decision-making."

基金机构：Yunnan Education Department of Science Research Fund [2023 J0295]; Department of Science and Technology of Yunnan Province Kunming Medical University Joint Project [202301AY070001-108]; Kunming City Health Science and Technology Talent "1000" training Project [2020-SW (Reserve)-112]; Kunming Medical Joint Project of Yunnan Science and Technology Department [202001AY070001-271]; Open Research Fund of Clinical Research Center for Children's Health and Diseases of Yunnan Province [2022-ETYY-YJ-03]

基金资助正文："This study was supported by Yunnan Education Department of Science Research Fund (No. 2023 J0295), Department of Science and Technology of Yunnan Province Kunming Medical University Joint Project (No. 202301AY070001-108), Kunming City Health Science and Technology Talent ""1000"" training Project (No. 2020-SW (Reserve)-112), Kunming Medical Joint Project of Yunnan Science and Technology Department (No. 202001 AY070001-271), and Open Research Fund of Clinical Research Center for Children's Health and Diseases of Yunnan Province (2022-ETYY-YJ-03). The funding bodies played no role in the study's design and collection, analysis and interpretation of data, and writing the manuscript."