Application of Human Stem Cell Derived Retinal Organoids in the Exploration of the Mechanisms of Early Retinal Development

作者全名："Kang, Jiahui; Gong, Jing; Yang, Cao; Lin, Xi; Yan, Lijuan; Gong, Yu; Xu, Haiwei"

作者地址："[Kang, Jiahui; Yang, Cao; Lin, Xi; Yan, Lijuan; Gong, Yu; Xu, Haiwei] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Southwest Eye Hosp, Chongqing 400038, Peoples R China; [Kang, Jiahui; Yang, Cao; Lin, Xi; Yan, Lijuan; Gong, Yu; Xu, Haiwei] Key Lab Visual Damage & Regenerat & Restorat Chong, Chongqing 400038, Peoples R China; [Gong, Jing] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China; [Gong, Yu] Chongqing Med Univ, Univ Town Hosp, Med Sci Res Ctr, Dept Ophthalmol, Chongqing, Peoples R China"

通信作者："Gong, Y; Xu, HW (通讯作者)，Third Mil Med Univ, Army Med Univ, Southwest Hosp, Southwest Eye Hosp, Chongqing 400038, Peoples R China.; Gong, Y; Xu, HW (通讯作者)，Key Lab Visual Damage & Regenerat & Restorat Chong, Chongqing 400038, Peoples R China.; Gong, Y (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Med Sci Res Ctr, Dept Ophthalmol, Chongqing, Peoples R China."

来源：STEM CELL REVIEWS AND REPORTS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001000603800002

JCR分区：Q2

影响因子：4.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Human Retinal organoids; Retinal development; Stem cells; Molecular mechanism

摘要："The intricate neural circuit of retina extracts salient features of the natural world and forms bioelectric impulse as the origin of vision. The early development of retina is a highly complex and coordinated process in morphogenesis and neurogenesis. Increasing evidence indicates that stem cells derived human retinal organoids (hROs) in vitro faithfully recapitulates the embryonic developmental process of human retina no matter in the transcriptome, cellular biology and histomorphology. The emergence of hROs greatly deepens on the understanding of early development of human retina. Here, we reviewed the events of early retinal development both in animal embryos and hROs studies, which mainly comprises the formation of optic vesicle and optic cup shape, differentiation of retinal ganglion cells (RGCs), photoreceptor cells (PRs) and its supportive retinal pigment epithelium cells (RPE). We also discussed the classic and frontier molecular pathways up to date to decipher the underlying mechanisms of early development of human retina and hROs. Finally, we summarized the application prospect, challenges and cutting-edge techniques of hROs for uncovering the principles and mechanisms of retinal development and related developmental disorder. hROs is a priori selection for studying human retinal development and function and may be a fundamental tool for unlocking the unknown insight into retinal development and disease."

基金机构：National Natural Science Foundation of China [31930068]; National Key Research and Development Program of China [2021YFA1101203]

基金资助正文：This work was supported by the National Natural Science Foundation of China grants 31930068; the National Key Research and Development Program of China grants 2021YFA1101203.