Gut microbiota: a new insight into neurological diseases

作者全名："Liu, Lanxiang; Wang, Haiyang; Chen, Xueyi; Xie, Peng"

作者地址："[Liu, Lanxiang; Xie, Peng] Chongqing Med Univ, Yongchuan Hosp, Dept Neurol, Chongqing 402160, Peoples R China; [Liu, Lanxiang; Wang, Haiyang; Chen, Xueyi; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Chongqing 400016, Peoples R China; [Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China"

通信作者："Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Chongqing 400016, Peoples R China."

来源：CHINESE MEDICAL JOURNAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001000827100001

JCR分区：Q1

影响因子：7.5

年份：2023

卷号：136

期号：11

开始页：1261

结束页：1277

文献类型：Review

关键词：Gut microbiota; Gut-brain axis; Neurological diseases; Parkinson's disease; Alzheimer's disease; Autism spectrum disorder; Cerebrovascular disease

摘要："In the last decade, it has become increasingly recognized that a balanced gut microbiota plays an important role in maintaining the health of the host. Numerous clinical and preclinical studies have shown that changes in gut microbiota composition are associated with a variety of neurological diseases, e.g., Parkinson's disease, Alzheimer's disease, and myasthenia gravis. However, the underlying molecular mechanisms are complex and remain unclear. Behavioral phenotypes can be transmitted from humans to animals through gut microbiota transplantation, indicating that the gut microbiota may be an important regulator of neurological diseases. However, further research is required to determine whether animal-based findings can be extended to humans and to elucidate the relevant potential mechanisms by which the gut microbiota regulates neurological diseases. Such investigations may aid in the development of new microbiota-based strategies for diagnosis and treatment and improve the clinical management of neurological disorders. In this review, we describe the dysbiosis of gut microbiota and the corresponding mechanisms in common neurological diseases, and discuss the potential roles that the intestinal microbiome may play in the diagnosis and treatment of neurological disorders."

基金机构："National Key R&D Program of China [2017YFA0505700]; Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences [2019PT320002]; Natural Science Foundation Project of China [81820108015]; China Postdoctoral Science Foundation [2020TQ0393, 2020M683634XB, 2021M693926]; Chongqing Science and Technology Commission [cstc2021jcyj-bsh0026, cstc2021jcyj-bsh0034]"

基金资助正文："This study was supported by the National Key R & D Program of China (No. 2017YFA0505700), the Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (No. 2019PT320002), the Natural Science Foundation Project of China (No. 81820108015), the China Postdoctoral Science Foundation (Nos. 2020TQ0393, 2020M683634XB, and 2021M693926), and the Chongqing Science and Technology Commission (Nos. cstc2021jcyj-bsh0026 and cstc2021jcyj-bsh0034)."