Intravitreal dexamethasone implants facilitate the management of refractory Behcet's uveitis with vasculitis

作者全名："Tao, Tianyu; Yang, Shizhao; He, Daquan; Li, Zhaohuai; Chen, Binyao; Zhu, Lei; Su, Wenru"

作者地址："[Tao, Tianyu; Yang, Shizhao; He, Daquan; Li, Zhaohuai; Chen, Binyao; Zhu, Lei; Su, Wenru] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou, Peoples R China; [Su, Wenru] Guangdong Prov Clin Res Ctr Ocular Dis, Guangzhou, Peoples R China; [Yang, Shizhao] Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 2, Chongqing, Peoples R China; [Su, Wenru] Sun Yat Sen Univ, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangdong Prov Clin Res Ctr Ocular Dis, State Key Lab Ophthalmol,Zhongshan Ophthalm Ctr, 54 Xianlie S Rd, Guangzhou 510000, Peoples R China"

通信作者："Su, WR (通讯作者)，Sun Yat Sen Univ, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangdong Prov Clin Res Ctr Ocular Dis, State Key Lab Ophthalmol,Zhongshan Ophthalm Ctr, 54 Xianlie S Rd, Guangzhou 510000, Peoples R China."

来源：CLINICAL IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001001099300001

JCR分区：Q2

影响因子：4.5

年份：2023

卷号：251

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Behcet's disease; Uveitis; Vasculitis; Dexamethasone; Ozurdex

摘要："To investigate the efficacy and safety of dexamethasone (DEX) implant, Ozurdex (R), as an adjunctive treatment for refractory Behcet's uveitis (BU), a total of 61 patients (80 eyes) were included in this cross-sectional study and divided into the non-DEX and DEX groups. After >12 months of treatment, the improvement in the fluorescein angiography score and vitritis score was significantly higher in the DEX group than in the non-DEX group. Although the posterior capsule opacification score was exacerbated, the rate of low-dose systemic glucocorticoid was higher and the relapse times were fewer in the DEX group. Therefore, Ozurdex (R) is an effective and safe option for patients with BU that are refractory to systemic immunosuppressant treatments by controlling vasculitis, stabilizing vitreous inflammation, preventing recurrence, and reducing daily glucocorticoid doses."

基金机构：National Outstanding Youth Science Fund Project of China [8212200477]; National Key Research and Development Program of China [2017YFA0105804]

基金资助正文：Funding This work was supported by the National Outstanding Youth Science Fund Project of China (No. 8212200477) and the National Key Research and Development Program of China (2017YFA0105804) .