Semen damage contributed over 50 % to air-pollutant-induced infertility: A prospective cohort study of 3940 men in China

作者全名："Guo, Ying; Chen, Qing; Zhan, Yu; Zhou, Wenzheng; Zhang, Haiyan; Zhou, Niya; Yang, Huan; Chen, Yi; Wang, Yimeng; Sun, Lei; Ao, Lin; Liu, Jinyi; Zhou, Wei; Qi, Hongbo; Cao, Jia"

作者地址："[Guo, Ying] Shanxi Med Univ, Sch Publ Hlth, Taiyuan, Peoples R China; [Guo, Ying; Chen, Qing; Yang, Huan; Chen, Yi; Wang, Yimeng; Sun, Lei; Ao, Lin; Liu, Jinyi; Cao, Jia] Army Med Univ, Mil Med Univ 3, Inst Toxicol, Coll Prevent Med, Chongqing, Peoples R China; [Zhan, Yu] Sichuan Univ, Dept Environm Sci & Engn, Chengdu, Sichuan, Peoples R China; [Zhou, Wenzheng; Zhou, Niya] Chongqing Med Univ, Women & Childrens Hosp, Dept Clin Res Ctr, Chongqing, Peoples R China; [Zhang, Haiyan; Zhou, Wei; Qi, Hongbo] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, 120 Longshan St, Chongqing 400038, Peoples R China; [Cao, Jia] Army Med Univ, Mil Med Univ 3, Inst Toxicol, Coll Prevent Med, 30 Gaotanyan St, Chongqing 400038, Peoples R China"

通信作者："Cao, J (通讯作者)，Army Med Univ, Mil Med Univ 3, Inst Toxicol, Coll Prevent Med, Chongqing, Peoples R China.; Qi, HB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China.; Qi, HB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, 120 Longshan St, Chongqing 400038, Peoples R China.; Cao, J (通讯作者)，Army Med Univ, Mil Med Univ 3, Inst Toxicol, Coll Prevent Med, 30 Gaotanyan St, Chongqing 400038, Peoples R China."

来源：SCIENCE OF THE TOTAL ENVIRONMENT

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:001001139600001

JCR分区：Q1

影响因子：8.2

年份：2023

卷号：885

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Ambient air pollution; Semen quality; Infertility; Mediation analysis; Joint effect

摘要："Objective: To investigate the contribution of ambient air pollutants-induced semen damage to infertility risk, after iden-tifying dose-response relationship between pollutants and semen parameters and susceptibility window. Methods: In Preconception Reproductive Health and Birth Outcomes Cohort, 3940 male volunteers aged 22-49 were recruited from November 2018 to April 2021. At enrollment, resident address information was obtained and semen parameters were examined. During prospective follow-up, infertility was defined as failure to achieve pregnancy after unprotected intercourse within 12 months. Full coverage of ambient pollutant (PM2.5, PM10, SO2, NO2, O3, CO) concentrations was estimated by machine learning algorithms and assigned to individual level. Association be-tween pollutants and semen parameters was analyzed by single-and two-pollutant linear regression. Four potential sus-ceptibility windows were analyzed: lag 0-9d, lag 10-14d, lag 70-90d and lag 0-90d. Pollutant joint effects on semen parameters were analyzed by Bayesian kernel machine regression. Mediating effect of semen parameters on the asso-ciation between pollutants and infertility was analyzed. False-positive rate was controlled by Bonferroni correction.Results: Single-and two-pollutant models showed SO2, O3, PMs and NO2 were negatively associated with progressive motility, total motility and sperm morphology, among which, each IQR increase in SO2 at lag 0-90d was associated with -4.13 %(95%CI:-6.25 %, -1.95 %, P < 0.001) change of normal morphology, and O3 at lag 0-90d was nega-tively associated with progressive motility and total motility (f3 = -3.64 %, 95%CI:-5.63 %, -1.61 %; f3 = -2.24 %, 95%CI:-3.38 %, -1.08 %, P < 0.001). Joint effect analysis showed a negative effect on sperm concentration and a suggestive effect on vitality. Mediating effect analysis showed sperm normal morphology had a substantial me-diating effect in the association of SO2 with infertility (59.68 %, P < 0.001). Conclusion: Multiple air pollutants may introduce semen quality in the population at entire window of spermatogenesis, among which SO2 needs especial attention, as its damage on sperm morphology may increase risk of infertility."

基金机构：National Key Research and Development Program of China [2022YFC2702900]; Key Program of National Natural Science Foundation of China [82130097]

基金资助正文：This work was supported by the National Key Research and Development Program of China [grant numbers: 2022YFC2702900] and the Key Program of National Natural Science Foundation of China (grant numbers: 82130097). Appreciation to Wang Tong for assist in the research.