Oxidative stress-related biomarkers in chronic periodontitis patients with or without type 2 diabetes: A systematic review and meta-analysis

作者全名："Chen, Sisi; Gao, Xiang; Song, Jinlin"

作者地址："[Chen, Sisi; Gao, Xiang; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Chen, Sisi; Gao, Xiang; Song, Jinlin] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Chen, Sisi; Gao, Xiang; Song, Jinlin] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China"

通信作者："Song, JL (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China."

来源：JOURNAL OF PERIODONTAL RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001002101200001

JCR分区：Q1

影响因子：3.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：biomarker; catalase; chronic periodontitis; oxidative stress; type 2 diabetes mellitus

摘要："ObjectiveThe purpose of this meta-analysis was to look at the differences in oxidative stress (OS) biomarkers between type 2 diabetes mellitus with chronic periodontitis (DMCP) and chronic periodontitis (CP) patients. BackgroundOxidative stress has been shown to be a key pathogenic component in DMCP. However, it is unclear whether oxidative stress levels differ in periodontitis patients with or without diabetes. MethodA systematic search was conducted on PubMed, Cochrane, and Embase databases. Studies of DMCP participants were used as the experimental group and CP participants were used as the control group. Results are expressed as mean effects. ResultsOf a total of 1989 articles, 19 met the inclusion criteria. We found the levels of catalase (CAT) levels were reduced in the DMCP group compared with the CP group. However, there was no significant difference in the levels of superoxide dismutase (SOD), total antioxidant capacity (TAOC) malondialdehyde (MDA), and glutathione (GSH) between the two groups. And high heterogeneity was observed in some of the studies evaluated. ConclusionDespite the limitations of this study, our results support the theory that there is an association between T2DM and the levels of OS-related biomarkers, especially CAT, in CP subjects, suggesting that OS plays an important role in the pathogenesis and development of DMCP."

基金机构：Chinese Key Project of Ministry of Science and Technology [2022YFC2504200]; National Natural Science Foundation of China [U22A20314]; Chongqing Graduate Tutor Team

基金资助正文："ACKNOWLEDGEMENTS This work was financially supported by funding from the Chinese Key Project of Ministry of Science and Technology (Grant NO. 2022YFC2504200), National Natural Science Foundation of China (Grant No. U22A20314), the Chongqing Graduate Tutor Team(Grant No. dstd201903)."