"The 'Ironclad friendship' of China-Cambodia, lays the first step in the foundation of early diagnosis and treatment of asymptomatic congenital heart Defects- A multi-national screening and intervention project, 2017-2020"

作者全名："Song, Honglin; Li, Xi; Lu, Jiang; Song, Junjie; Wang, Teng; Gao, Min; Zhang, Xingyi; Ma, Min; Shi, Yi; Fang, Jiayu; Fu, Hongchen; Wang, Huadan; Duo, Lin; Tang, Mingjing; Pang, Linhong"

作者地址："[Song, Honglin; Lu, Jiang; Song, Junjie; Wang, Teng; Shi, Yi; Duo, Lin; Tang, Mingjing; Pang, Linhong] Kunming Med Univ, Fuwai Yunnan Cardiovasc Hosp, Cardiovasc Hosp, Kunming, Peoples R China; [Song, Honglin; Ma, Min; Fang, Jiayu; Fu, Hongchen; Wang, Huadan; Pang, Linhong] Kunming Med Univ, Sch Publ Hlth, Yu Hua St Chun Rong Rd, Kunming, Peoples R China; [Li, Xi; Zhang, Xingyi] Fuwai Hosp, Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Cardiovasc Dis,Natl Ctr Cardiovasc D, Beijing, Peoples R China; [Li, Xi] Natl Ctr Cardiovasc Dis, Cent China Subctr, Zhengzhou, Peoples R China; [Gao, Min] Chongqing Med Univ, Sch Publ Hlth, Jinyun Campus, Chongqing, Peoples R China"

通信作者："Tang, MJ; Pang, LH (通讯作者)，Kunming Med Univ, Fuwai Yunnan Cardiovasc Hosp, Cardiovasc Hosp, Kunming, Peoples R China.; Pang, LH (通讯作者)，Kunming Med Univ, Sch Publ Hlth, Yu Hua St Chun Rong Rd, Kunming, Peoples R China."

来源：BMC CARDIOVASCULAR DISORDERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001002342300002

JCR分区：Q3

影响因子：2

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Congenital heart disease; Prevalence; China; Cambodia; Asymptomatic; Children

摘要："Background Congenital heart disease (CHD) is the leading cause of mortality in childhood worldwide. However, a large number of children with CHD are not diagnosed promptly in low- and middle-income regions, due to limited healthcare resources and lack the ability of prenatal and postnatal ultrasound examinations. The research on asymptomatic CHD in the community is still blank, resulting in a large number of children with asymptomatic CHD can not be found and treated in time. Through the China-Cambodia collaborative health care initiative, the project team conducted research, screened children's CHD through a sampling survey in China and Cambodia, collected relevant data, and retrospectively analyzed the data of all eligible patients. Objectives The project aimed to evaluate the prevalence of asymptomatic CHD in a sample population of 3-18years old and effects on their growth status and treatment outcomes. Methods We examined the prevalence of `asymptomatic CHD' among 3-18years old children and adolescents at the township/county levels in the two participating. A total of eight provinces in China and five provinces in Cambodia were analyzed from 2017 to 2020. During 1 year follow-up after treatment, the differences in heights and weights of the treated and control groups were evaluated. Results Among the 3,068,075 participants screened from 2017 to 2020, 3967 patients with asymptomatic CHD requiring treatment were identified [0.130%, 95% confidence interval (CI) 0.126 -0.134%]. The prevalence rate of CHD ranged from 0.02 to 0.88%, and was negatively related to local per capita GDP (p = 0.028). The average height of 3310 treated CHD patients were 2.23% (95% CI: -2.51%similar to-1.9%) lower than that of the standard group and the average weight was - 6.41% (95% CI: -7.17%similar to-5.65%) lower, the developmental gap widening with advancing age. One year after treatment, the relative height difference remained comparable while that, in weight was reduced by 5.68% (95% CI: 4.27% similar to 7.09%). Conclusions Asymptomatic CHD now is often overlooked and is an emerging public health challenge. Early detection and treatment are essential to lower the potential burden of heart diseases in children and adolescents."

基金机构：　

基金资助正文：