High preoperative CEA and systemic inflammation response index (C-SIRI) predict unfavorable survival of resectable colorectal cancer

作者全名："Cai, Hao; Chen, Yu; Zhang, Qiao; Liu, Yang; Jia, HouJun"

作者地址："[Cai, Hao; Chen, Yu; Zhang, Qiao; Liu, Yang; Jia, HouJun] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, 1,Med Coll Rd,Yuzhong Dist, Chongqing 400016, Peoples R China"

通信作者："Jia, HJ (通讯作者)，Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, 1,Med Coll Rd,Yuzhong Dist, Chongqing 400016, Peoples R China."

来源：WORLD JOURNAL OF SURGICAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001002638900001

JCR分区：Q1

影响因子：2.5

年份：2023

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Systemic inflammation response index; Colorectal cancer; Carcinoembryonic antigen; Prognosis

摘要："BackgroundCEA and systemic inflammation were reported to correlate with proliferation, invasion, and metastasis of colorectal cancer. This study investigated the prognostic significance of the preoperative CEA and systemic inflammation response index (C-SIRI) in patients with resectable colorectal cancer.MethodsTwo hundred seventeen CRC patients were recruited from Chongqing Medical University, the first affiliated hospital, between January 2015 and December 2017. Baseline characteristics, preoperative CEA level, and peripheral monocyte, neutrophil, and lymphocyte counts were retrospectively reviewed. The optimal cutoff value for SIRI was defined as 1.1, and for CEA, the best cutoff values were 4.1 ng/l and 13.0 ng/l. Patients with low levels of CEA (< 4.1 ng/l) and SIRI (< 1.1) were assigned a value of 0, those with high levels of CEA (>= 13.0 ng/l) and SIRI (>= 1.1) were assigned a value of 3, and those with CEA (4.1-13.0 ng/l) and SIRI (>= 1.1), CEA (>= 13.0 ng/l), and SIRI (< 1.1) were assigned a value of 2. Those with CEA (< 4.1 ng/l) and SIRI (>= 1.1) and CEA (4.1-13.0 ng/l) and SIRI (< 1.1) were assigned a value of 1. The prognostic value was assessed based on univariate and multivariate survival analysis.ResultsPreoperative C-SIRI was statistically correlated with gender, site, stage, CEA, OPNI, NLR, PLR, and MLR. However, no difference was observed between C-SIRI and age, BMI, family history of cancer, adjuvant therapy, and AGR groups. Among these indicators, the correlation between PLR and NLR is the strongest. In addition, high preoperative C-SIRI was significantly correlated with poorer overall survival (OS) (HR: 2.782, 95% CI: 1.630-4.746, P < 0.001) based on univariate survival analysis. Moreover, it remained an independent predictor for OS (HR: 2.563, 95% CI: 1.419-4.628, p = 0.002) in multivariate Cox regression analysis.ConclusionOur study showed that preoperative C-SIRI could serve as a significant prognostic biomarker in patients with resectable colorectal cancer."

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