LRFN5 and OLFM4 as novel potential biomarkers for major depressive disorder: a pilot study

作者全名："Xu, Ke; Zheng, Peng; Zhao, Shuang; Wang, Jiubing; Feng, Jinzhou; Ren, Yi; Zhong, Qi; Zhang, Hanping; Chen, Xiangyu; Chen, Jianjun; Xie, Peng"

作者地址："[Xu, Ke; Zheng, Peng; Feng, Jinzhou; Ren, Yi; Zhang, Hanping; Chen, Xiangyu; Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Xu, Ke; Zheng, Peng; Ren, Yi; Zhang, Hanping; Chen, Xiangyu; Xie, Peng] Chongqing Med Univ, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhao, Shuang] Chongqing Med Univ, Dept Pathophysiol, Chongqing, Peoples R China; [Wang, Jiubing] Chongqing Mental Hlth Ctr, Dept Clin Lab, Chongqing, Peoples R China; [Zhong, Qi; Chen, Jianjun] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China"

通信作者："Xie, P (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Affiliated Hosp 1, Chongqing, Peoples R China.; Chen, JJ (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China."

来源：TRANSLATIONAL PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001002724500003

JCR分区：Q1

影响因子：5.8

年份：2023

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Evidences have shown that both LRFN5 and OLFM4 can regulate neural development and synaptic function. Recent genome-wide association studies on major depressive disorder (MDD) have implicated LRFN5 and OLFM4, but their expressions and roles in MDD are still completely unclear. Here, we examined serum concentrations of LRFN5 and OLFM4 in 99 drug-naive MDD patients, 90 drug-treatment MDD patients, and 81 healthy controls (HCs) using ELISA methods. The results showed that both LRFN5 and OLFM4 levels were considerably higher in MDD patients compared to HCs, and were significantly lower in drug-treatment MDD patients than in drug-naive MDD patients. However, there were no significant differences between MDD patients who received a single antidepressant and a combination of antidepressants. Pearson correlation analysis showed that they were associated with the clinical data, including Hamilton Depression Scale score, age, duration of illness, fasting blood glucose, serum lipids, and hepatic, renal, or thyroid function. Moreover, these two molecules both yielded fairly excellent diagnostic performance in diagnosing MDD. In addition, a combination of LRFN5 and OLFM4 demonstrated a better diagnostic effectiveness, with an area under curve of 0.974 in the training set and 0.975 in the testing set. Taken together, our data suggest that LRFN5 and OLFM4 may be implicated in the pathophysiology of MDD and the combination of LRFN5 and OLFM4 may offer a diagnostic biomarker panel for MDD."

基金机构：National Key R&D Program of China [2017YFA0505700]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT320002]; National Natural Science Foundation of China [81820108015]; First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation [CYYY-BSHPYXM-202310]

基金资助正文："We thank the Department of Psychiatry, First Hospital of Chongqing Medical University for their help with human blood collection. This work was supported by the National Key R & D Program of China (2017YFA0505700), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320002), the National Natural Science Foundation of China (81820108015), and the First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation (CYYY-BSHPYXM-202310)."