Effect of dexmedetomidine on liver transplantation: a meta-analysis

作者全名："Jia, Degong; Guo, Shanshan; Wu, Xinyi; Zhao, Minjie; Luo, Jiefu; Cheng, Mingxiang; Qin, Yajun"

作者地址："[Jia, Degong; Wu, Xinyi; Zhao, Minjie; Luo, Jiefu; Cheng, Mingxiang; Qin, Yajun] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Guo, Shanshan] Anhui Med Univ, Dept Nephrol, Affiliated Hosp 1, Hefei, Peoples R China"

通信作者："Qin, YJ (通讯作者)，Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001002778200001

JCR分区：Q1

影响因子：4.4

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：liver transplantation; dexmedetomedine; liver function; complication; meta-analysis

摘要："Background: Dexmedetomidine (DEX), an adjuvant anesthetic, may improve the clinical outcomes of liver transplantation (LT).Methods: We summarized the relevant clinical trials of DEX in patients undergoing LT. As of 30 January 2023, we searched The Cochrane Library, MEDLINE, EMBASE, and the WHO ICTRP. The main outcomes were postoperative liver and renal function. The random effect model or fixed effect model was used to summarize the outcomes across centers based on the differences in heterogeneity.Results: The meta-analysis included nine studies in total. Compared with the control group, the DEX group had a reduced warm ischemia time (MD-4.39; 95% CI-6.74--2.05), improved postoperative liver (peak aspartate transferase: MD-75.77, 95% CI-112.81--38.73; peak alanine transferase: MD-133.51, 95% CI-235.57--31.45) and renal function (peak creatinine: MD-8.35, 95% CI-14.89--1.80), and a reduced risk of moderate-to-extreme liver ischemia-reperfusion injury (OR 0.28, 95% CI 0.14-0.60). Finally, the hospital stay of these patients was decreased (MD-2.28, 95% CI-4.00--0.56). Subgroup analysis of prospective studies showed that DEX may have better efficacy in living donors and adult recipients.Conclusion: DEX can improve short-term clinical outcomes and shorten the hospital stay of patients. However, the long-term efficacy of DEX and its interfering factors deserves further study.Systematic Review: identifier CRD42022351664."

基金机构：Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202000405]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0791]

基金资助正文：Funding This research was funded by the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202000405) and the Natural Science Foundation of Chongqing (Grant No. cstc2020jcyj-msxmX0791).