Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

作者全名："Jin, Chen; Luo, Yuxiao; Liang, Zhu; Li, Xi; Kolat, Damian; Zhao, Linyong; Xiong, Weixi"

作者地址："[Jin, Chen] Chongqing Med Univ, Dept Cardiothorac Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Luo, Yuxiao] Univ Gottingen, Univ Med Ctr Gottingen, Gottingen, Germany; [Liang, Zhu] Univ Oxford, Chinese Acad Med Sci Oxford Inst, Nuffield Dept Med, Target Discovery Inst,Ctr Med Discovery, Oxford, England; [Li, Xi] Oxford Univ Hosp NHS Fdn, Churchill Hosp, Dept Urol, Oxford, England; [Kolat, Damian] Med Univ Lodz, Dept Expt Surg, Lodz, Poland; [Zhao, Linyong] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, Dept Gen Surg, Chengdu, Peoples R China; [Zhao, Linyong] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, Lab Gastr Canc,State Key Lab Biotherapy, Chengdu, Peoples R China; [Zhao, Linyong] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China; [Zhao, Linyong] Sichuan Univ, West China Hosp, Gastr Canc Ctr, Chengdu, Peoples R China; [Xiong, Weixi] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Peoples R China; [Xiong, Weixi] Sichuan Univ, West China Hosp, Inst Brain Sci & Brain Inspired Technol, Chengdu, Peoples R China; [Jin, Chen] Sichuan Univ, West China Hosp, Dept Liver Surg, Chengdu, Peoples R China"

通信作者："Zhao, LY (通讯作者)，Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, Dept Gen Surg, Chengdu, Peoples R China.; Zhao, LY (通讯作者)，Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, Lab Gastr Canc,State Key Lab Biotherapy, Chengdu, Peoples R China.; Zhao, LY (通讯作者)，Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China.; Zhao, LY (通讯作者)，Sichuan Univ, West China Hosp, Gastr Canc Ctr, Chengdu, Peoples R China.; Xiong, WX (通讯作者)，Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Peoples R China.; Xiong, WX (通讯作者)，Sichuan Univ, West China Hosp, Inst Brain Sci & Brain Inspired Technol, Chengdu, Peoples R China."

来源：JOURNAL OF TRANSLATIONAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001003697600001

JCR分区：Q1

影响因子：6.1

年份：2023

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Activator protein 2; Transcription factor; Cancer stemness; Epithelial-mesenchymal transition; Tumor microenvironment; Ferroptosis

摘要："The transcription factor family activator protein 2 (TFAP2) is vital for regulating both embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E. The importance of TFAP2 in tumor biology is becoming more widely recognized. While TFAP2D is not well studied, here, we mainly focus on the other four TFAP2 members. As a transcription factor, TFAP2 regulates the downstream targets directly by binding to their regulatory region. In addition, the regulation of downstream targets by epigenetic modification, posttranslational regulation, and interaction with noncoding RNA have also been identified. According to the pathways in which the downstream targets are involved in, the regulatory effects of TFAP2 on tumorigenesis are generally summarized as follows: stemness and EMT, interaction between TFAP2 and tumor microenvironment, cell cycle and DNA damage repair, ER- and ERBB2-related signaling pathway, ferroptosis and therapeutic response. Moreover, the factors that affect TFAP2 expression in oncogenesis are also summarized. Here, we review and discuss the most recent studies on TFAP2 and its effects on carcinogenesis and regulatory mechanisms."

基金机构：　

基金资助正文：