Relationship Between Mechanoreceptors in the Posterior Cruciate Ligament and Patient Age or Osteoarthritis Severity

作者全名："Chen, Jinlong; Chen, Shirong"

作者地址："[Chen, Shirong] Chongqing Med Univ, Orthoped & Joint Surg, Affiliated Hosp 2, 265 Daping Street, Chongqing 400010, Peoples R China; [Chen, Jinlong; Chen, Shirong] Chongqing Med Univ, Affiliated Hosp 2, Orthoped & Joint Surg, Chongqing, Peoples R China"

通信作者："Chen, SR (通讯作者)，Chongqing Med Univ, Orthoped & Joint Surg, Affiliated Hosp 2, 265 Daping Street, Chongqing 400010, Peoples R China."

来源：ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001003783900001

JCR分区：Q2

影响因子：2.4

年份：2023

卷号：11

期号：6

开始页：　

结束页：　

文献类型：Article

关键词：mechanoreceptor; posterior cruciate ligament; PCL; total knee arthroplasty; TKA; osteoarthritis; age; Western Ontario and McMaster Universities Osteoarthritis Index; WOMAC

摘要："Background:Mechanoreceptors in the posterior cruciate ligament (PCL) can produce proprioception, which is an important reason why patients choose cruciate-retaining total knee arthroplasty (TKA). The number of mechanoreceptors in the PCL of patients with knee osteoarthritis (OA) is unknown. Purpose:To provide a theoretical basis for estimating the number of mechanoreceptors in the PCL by evaluating the relationship between this number and patient age or OA severity. Study Design:Cross-sectional study; Level of evidence, 3. Methods:An overall 28 PCLs from patients with knee OA were collected at the time of TKA and grouped according to patient age (group A, 60-69 years [n = 8]; group B, 70-79 years [n = 12]; group C, >= 80 years [n = 8]) and OA based on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (group I, <= 80 [n = 8]; group II, 81-120 [n = 10]; group III, >120 [n = 10]). Hematoxylin and eosin and S-100 immunohistochemical staining were performed on the slices near the tibial attachment of the PCL, and the number of mechanoreceptors in each slice was counted. Multifactor analysis of variance was used to evaluate the relationship between the number of mechanoreceptors and patient age or WOMAC score. Results:The number of mechanoreceptors (mean +/- SD) in groups A, B, and C was 24.00 +/- 15.19, 30.92 +/- 11.41, and 23.38 +/- 11.39, respectively, with no significant between-group differences. The number of mechanoreceptors in groups I, II, and III was 43.50 +/- 4.99, 25.00 +/- 5.27, and 15.20 +/- 5.61, with significant differences between groups I and II, groups I and III, and groups II and III (P < .001 for all). Conclusion:In patients with knee OA, age had no significant effect on mechanoreceptor count, but the number of mechanoreceptors in the PCL decreased significantly with higher (worse) WOMAC score. These findings suggest that in patients of any age with high WOMAC scores, there may be little value as it relates to knee proprioception in performing a PCL-retaining TKA."

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