The Association of Remnant Cholesterol with Endothelial Dysfunction and Subclinical Atherosclerosis in a Check-Up Population in China

作者全名："Yang, Ping-ting; Li, Ying; Wang, Jian-gang; Zhang, Li-jun; Yang, Sai-qi; Tang, Li; Chen, Qian; Shi, Qiu-ling"

作者地址："[Yang, Ping-ting; Yang, Sai-qi; Tang, Li; Shi, Qiu-ling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Yang, Ping-ting] Chongqing Haifu Med Technol Co Ltd, Chongqing, Peoples R China; [Yang, Ping-ting; Li, Ying; Wang, Jian-gang; Yang, Sai-qi; Chen, Qian] Cent South Univ, Xiangya Hosp 3, Dept Hlth Management, Changsha, Hunan, Peoples R China; [Zhang, Li-jun] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Shi, Qiu-ling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Yixueyuan Rd, Yuzhong Dist, Chongqing 400016, Peoples R China"

通信作者："Shi, QL (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Yixueyuan Rd, Yuzhong Dist, Chongqing 400016, Peoples R China."

来源：JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001006032900001

JCR分区：Q2

影响因子：3

年份：2023

卷号：30

期号：6

开始页：684

结束页：697

文献类型：Article

关键词：Remnant cholesterol; Brachial-ankle pulse wave velocity; Flow-mediated vasodilation; Endothelial dysfunction; Subclinical atherosclerosis; Check-up population

摘要："Aim: Vascular endothelial function and atherosclerosis are known to be important risk factors for cardiovascular disease. However, it remains unknown whether remnant cholesterol (RC) correlates with vascular endothelial function and atherosclerosis as represented by flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV). Therefore, in this study, we aimed to investigate this in the general population.Methods: In this study, we examined 13,237 subjects who have undergone blood lipid, FMD, and baPWV measurements. Participants were divided into four groups based on RC quartiles. Multivariable linear regression models were used to calculate odds ratios for FMD and baPWV according to the RC levels.Results: A significant negative relationship was found between RC and FMD (beta=-0.14, p=0.014), whereas RC was positively associated with baPWV (beta=21.42, p<0.001), especially in the male and without chronic disease medication populations. The population was divided into three groups according to their lipids: dyslipidemia group, nondyslipidemia but RC increased group (RC >0.78 mmol/L), and nondyslipidemia and RC normal group (RC <= 0.78 mmol/L). The FMD of the three groups was 7.09%+/- 3.36%, 7.39%+/- 3.38%, and 7.57%+/- 3.54%, respectively. The baPWV of the three groups was 1445.26 +/- 261.56 cm/s, 1425.04 +/- 265.24 cm/s, and 1382.73 +/- 267.75 cm/s. Significant differences were noted between the groups. Conclusions: The findings indicated that a higher RC was an independent predictive factor for participants with endothelial function and atherosclerosis. It is important to use RC as a risk management indicator of vascular function, especially for those with normal conventional lipid parameters but increased RC."

基金机构：National Key R&D Program of China [2021YFC2500500]; National Science Foundation of China [81973324]; Hunan Young Talent grant [2020RC3063]; Hunan Science Foundation [2019JJ50915]

基金资助正文："Financial Support This work was supported by funding from the National Key R&D Program of China (2021YFC2500500) , National Science Foundation of China (81973324) , Hunan Young Talent grant (2020RC3063) , and Hunan Science Foundation (2019JJ50915) ."