Risk factors for recurrence after surgical repair of coarctation of the aorta in children: a single-center experience based on 51 children

作者全名："Zhao, Zhenjiang; Pan, Zhengxia; Wu, Chun; Tian, Jie; Qin, Jinjie; Zhang, Yulin; Jin, Xin"

作者地址："[Zhao, Zhenjiang; Pan, Zhengxia; Wu, Chun; Jin, Xin] Chongqing Med Univ, Dept Cardiothorac Surg, Childrens Hosp, Chongqing, Peoples R China; [Zhao, Zhenjiang; Pan, Zhengxia; Wu, Chun; Jin, Xin] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Zhao, Zhenjiang; Pan, Zhengxia; Wu, Chun; Jin, Xin] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Zhao, Zhenjiang; Pan, Zhengxia; Wu, Chun; Jin, Xin] China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China; [Zhao, Zhenjiang; Pan, Zhengxia; Wu, Chun; Jin, Xin] Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Tian, Jie] Chongqing Med Univ, Dept Cardiol, Childrens Hosp, Chongqing, Peoples R China; [Qin, Jinjie] Chongqing Med Univ, Dept Radiol, Childrens Hosp, Chongqing, Peoples R China; [Zhang, Yulin] Intelligence Med Sci & Technol Commiss, Chongqing, Peoples R China"

通信作者："Jin, X (通讯作者)，Chongqing Med Univ, Dept Cardiothorac Surg, Childrens Hosp, Chongqing, Peoples R China.; Jin, X (通讯作者)，Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China.; Jin, X (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China.; Jin, X (通讯作者)，China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China.; Jin, X (通讯作者)，Chongqing Key Lab Pediat, Chongqing, Peoples R China."

来源：FRONTIERS IN CARDIOVASCULAR MEDICINE

ESI学科分类：　

WOS号：WOS:001006122500001

JCR分区：Q2

影响因子：2.8

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：coarctation of the aorta (COA); congenital heart disease; cardiac; pediatrics; children; risk factor; surgical treatment

摘要："BackgroundCoarctation of the aorta (CoA), is a congenital malformation, often combined with several cardiac abnormalities. At present, the operation effect is satisfactory, but postoperative restenosis is still a matter. Identification of risk factors for restenosis and prompt therapy adjustments may improve patient outcomes. Materials and methodsA retrospective clinical study of patients under 12 who had CoA repair in 2012-2021, with a randomized cohort population of 475 patients. ResultsA total of 51 patients (M/F: 30/21) with a mean age of 5.33 (2.00-15.00) months and a median weight of 5.60 (4.20-10.00) kg. The mean follow-up was 8.93 (3.77-19.37) months. Patients were divided into 2 groups: no-restenosis (n-reCoA) (G1, 38 patients) and restenosis (reCoA) (G2, 13 patients). ReCoA was defined as a restenosis requiring interventional or surgery or a pressure gradient >20 mmHg at the repair site as reported by B-ultrasound with the presence of an upper and lower limb blood pressure gradient or growing dysplasia. The overall reCoA incidence was 25% (13/51). In multivariate COX regression, smaller preoperative z-score of the ascending aorta (P = 0.009, HR = 0.68) and transverse aortic arch (P = 0.015, HR = 0.66), arm-leg systolic pressure gradient >= 12.5 mmHg at discharge (P = 0.003, HR = 1.09) were independent risk factors for reCoA. ConclusionThe overall outcome of CoA surgery is successful. Smaller preoperative z-score of the ascending aorta and transverse aortic arch, and an arm-leg systolic pressure gradient >= 12.5 mmHg at discharge increase reCoA risk, and closer follow-up for such patients are required especially within 1 postoperative year."

基金机构：　

基金资助正文：