Chemerin as an Inducer of beta Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes beta Cell Mass Expansion

作者全名："Li, Min; Zhang, Ruifan; Ge, Qian; Yue, Lingzhi; Ma, Dan; Khattab, Firas; Xie, Wenhua; Cui, Yewei; Gilon, Patrick; Zhao, Xueya; Li, Xi; Cheng, Rui"

作者地址："[Li, Min; Zhang, Ruifan; Yue, Lingzhi; Ma, Dan; Xie, Wenhua; Cui, Yewei; Zhao, Xueya; Li, Xi; Cheng, Rui] Chongqing Med Univ, Inst Life Sci, Sch Basic Med, Chongqing 400016, Peoples R China; [Ge, Qian] Chongqing Med Univ, Clin Coll 1, Chongqing 400016, Peoples R China; [Khattab, Firas; Gilon, Patrick] Catholic Univ Louvain, Inst Rech Expt & Clin, Pole Endocrinol Diabet & Nutr, B-1200 Brussels, Belgium"

通信作者："Li, X; Cheng, R (通讯作者)，Chongqing Med Univ, Inst Life Sci, Sch Basic Med, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ESI学科分类：CHEMISTRY

WOS号：WOS:001006261700001

JCR分区：Q1

影响因子：4.9

年份：2023

卷号：24

期号：11

开始页：　

结束页：　

文献类型：Article

关键词：chemerin; beta cell; adipokine; insulin secretion; mitochondrial homeostasis; type 2 diabetes

摘要："Loss of the beta cell population is a crucial feature of type 2 diabetes. Restoring the beta cell mass by stimulating beta cell proliferation and preventing its apoptosis was proposed as a therapeutic approach to treating diabetes. Therefore, researchers have been increasingly interested in identifying exogenous factors that can stimulate beta cell proliferation in situ and in vitro. Adipokine chemerin, which is secreted from adipose tissue and the liver, has been identified as a chemokine that plays a critical role in the regulation of metabolism. In this study, we demonstrate that chemerin as a circulating adipokine promotes beta cell proliferation in vivo and in vitro. Chemerin serum levels and the expression of the main receptors within islets are highly regulated under a variety of challenging conditions, including obesity and type 2 diabetes. As compared to their littermates, mice overexpressing chemerin had a larger islet area and increased beta cell mass with both a normal and high-fat diet. Moreover, in chemerin-overexpressed mice, we observed improved mitochondrial homeostasis and increased insulin synthesis. In summary, our findings confirm the potential role of chemerin as an inducer of beta cell proliferation, and they provide novel insights into the helpful strategy to expand beta cell population."

基金机构："National Key R&D Program of China [2018YFA0800401]; National Natural Science Foundation of China [81770861, 82070899, 82011530460]; Natural Sciences Foundation of Chongqing [CSTB2022NSCQ-MSX0827]; program for Youth Innovation in Future Medicine, Chongqing Medical University [W0046]; fundamental research and frontier exploration project of Yuzhong district, Chongqing [20210123]; Innovation Program for the Returned Overseas Scholar of Chongqing [X20029]; High-end Foreign Experts Recruitment Plan of Ministry of Science and Technology of China [G2022035002L]; PDR Grant [T.0110.20]; Fonds National de la Recherche Scientifique (FNRS, Brussels); FRIA/FNRS (Brussels)"

基金资助正文："This research was funded by the National Key R&D Program of China (2018YFA0800401); the National Natural Science Foundation of China (81770861, 82070899, and 82011530460); the general project of the Natural Sciences Foundation of Chongqing (CSTB2022NSCQ-MSX0827); the program for Youth Innovation in Future Medicine, Chongqing Medical University, (W0046); the fundamental research and frontier exploration project of Yuzhong district, Chongqing (20210123); the Innovation Program for the Returned Overseas Scholar of Chongqing (X20029); and the High-end Foreign Experts Recruitment Plan of Ministry of Science and Technology of China (G2022035002L). P.G. was supported by a PDR Grant (T.0110.20) from the Fonds National de la Recherche Scientifique (FNRS, Brussels). P.G. is Research Director of the FNRS and F.K. is holder of a fellowship from the FRIA/FNRS (Brussels)."