Regional microstructural differences in ADHD youth with and without a family history of bipolar I disorder

作者全名："Lei, Du; Qin, Kun; Li, Wenbin; Zhu, Ziyu; Tallman, Maxwell J.; Patino, L. Rodrigo; Fleck, David E.; Aghera, Veronica; Gong, Qiyong; Sweeney, John A.; DelBello, Melissa P.; McNamara, Robert K."

作者地址："[Lei, Du] Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China; [Lei, Du; Qin, Kun; Li, Wenbin; Zhu, Ziyu; Tallman, Maxwell J.; Patino, L. Rodrigo; Fleck, David E.; Aghera, Veronica; Sweeney, John A.; DelBello, Melissa P.; McNamara, Robert K.] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Coll Med, Cincinnati, OH 45219 USA; [Qin, Kun; Li, Wenbin; Zhu, Ziyu; Gong, Qiyong; Sweeney, John A.] Sichuan Univ, Huaxi MR Res Ctr HMRRC, Ctr Med Imaging, Dept Radiol,West China Hosp, Chengdu 610041, Peoples R China; [Lei, Du] Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China; [Gong, Qiyong] Sichuan Univ, Huaxi MR Res Ctr, West China Hosp, Chengdu, Sichuan, Peoples R China"

通信作者："Lei, D (通讯作者)，Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China.; Gong, QY (通讯作者)，Sichuan Univ, Huaxi MR Res Ctr, West China Hosp, Chengdu, Sichuan, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001006851700001

JCR分区：Q1

影响因子：4.9

年份：2023

卷号：334

期号：　

开始页：238

结束页：245

文献类型：Article

关键词：ADHD; DTI; Bipolar disorder; Limbic system; Fractional anisotropy; Mean diffusivity

摘要："Background: Having a first-degree relative with bipolar I disorder (BD) in conjunction with prodromal attention deficit/hyperactivity disorder (ADHD) may represent a unique phenotype that confers greater risk for developing BD than ADHD alone. However, underlying neuropathoetiological mechanisms remain poorly understood. This cross-sectional study compared regional microstructure in psychostimulant-free ADHD youth with ('high-risk', HR) and without ('low-risk', LR) a first-degree relative with BD, and healthy controls (HC).Methods: A total of 140 (high-risk, n = 44; low-risk, n = 49; and HC, n = 47) youth (mean age: 14.1 +/- 2.5 years, 65 % male) were included in the analysis. Diffusion tensor images were collected and fractional anisotropy (FA) and mean diffusivity (MD) maps were calculated. Both tract-based and voxel-based analyses were performed. Correlations between clinical ratings and microstructural metrics that differed among groups were examined.Results: No significant group differences in major long-distance fiber tracts were observed. The high-risk ADHD group exhibited predominantly higher FA and lower MD in frontal, limbic, and striatal subregions compared with the low-risk ADHD group. Both low-risk and high-risk ADHD groups exhibited higher FA in unique and overlapping regions compared with HC subjects. Significant correlations between regional microstructural metrics and clinical ratings were observed in ADHD groups.Limitations: Prospective longitudinal studies will be required to determine the relevance of these findings to BD risk progression. Conclusions: Psychostimulant-free ADHD youth with a BD family history exhibit different microstructure alterations in frontal, limbic, and striatal regions compared with ADHD youth without a BD family history, and may therefore represent a unique phenotype relevant to BD risk progression."

基金机构：R01 NIMH [097818]; Chongqing Talents Exceptional Young Talents Project

基金资助正文：This study was supported by R01 NIMH grant 097818 to R.K.M and M.P.D. Du Lei was supported by Chongqing Talents Exceptional Young Talents Project.