Extensive genetic admixture between Tai-Kadai-speaking people and their neighbours in the northeastern region of the Yungui Plateau inferred from genome-wide variations

作者全名："Wang, Jiawen; Wu, Jun; Sun, Qiuxia; Wu, Qian; Li, Youjing; Duan, Shuhan; Yang, Lin; Wu, Wenxin; Wang, Zheng; Liu, Yan; Tang, Renkuan; Yang, Junbao; Wang, Chuanchao; Liu, Chao; Xu, Jianwei; Wang, Mengge; He, Guanglin"

作者地址："[Wang, Jiawen; Wu, Jun; Yang, Lin; Wu, Wenxin] Guizhou Med Univ, Sch Forens Med, Guiyang 550004, Peoples R China; [Sun, Qiuxia; Duan, Shuhan; Liu, Yan; He, Guanglin] Sichuan Univ, West China Hosp, Inst Rare Dis, Chengdu 610000, Peoples R China; [Sun, Qiuxia; Tang, Renkuan] Chongqing Med Univ, Coll Basic Med, Dept Forens Med, Chongqing 400331, Peoples R China; [Wu, Qian] Qiannan Prefecture Peoples Hosp, Buyi & Miao Autonomous Prefecture QianNan, Guizhou 558000, Peoples R China; [Li, Youjing] Congjiang Peoples Hosp, Congjiang 557499, Peoples R China; [Duan, Shuhan; Liu, Yan; Yang, Junbao] North Sichuan Med Coll, Sch Basic Med Sci, Nanchong 637000, Peoples R China; [Wang, Zheng] Sichuan Univ, Inst Forens Med, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China; [Wang, Chuanchao] Xiamen Univ, Inst Anthropol, Sch Sociol & Anthropol, Dept Anthropol & Ethnol, Xiamen 361000, Peoples R China; [Liu, Chao; Wang, Mengge] Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou 510275, Peoples R China; [Xu, Jianwei] Guizhou Med Univ, Sch Basic Med, Dept Pharmacol, Guiyang 550004, Peoples R China; [He, Guanglin] Sichuan Univ, Ctr Archaeol Sci, Chengdu 610000, Peoples R China"

通信作者："Wang, JW (通讯作者)，Guizhou Med Univ, Sch Forens Med, Guiyang 550004, Peoples R China.; He, GL (通讯作者)，Sichuan Univ, West China Hosp, Inst Rare Dis, Chengdu 610000, Peoples R China.; Wang, MG (通讯作者)，Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou 510275, Peoples R China.; Xu, JW (通讯作者)，Guizhou Med Univ, Sch Basic Med, Dept Pharmacol, Guiyang 550004, Peoples R China.; He, GL (通讯作者)，Sichuan Univ, Ctr Archaeol Sci, Chengdu 610000, Peoples R China."

来源：BMC GENOMICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001007705900001

JCR分区：Q2

影响因子：3.5

年份：2023

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Biological adaptation; Genome-wide SNPs; Genetic admixture model; TK people

摘要："BackgroundYungui Plateau in Southwest China is characterized by multi-language and multi-ethnic communities and is one of the regions with the wealthiest ethnolinguistic, cultural and genetic diversity in East Asia. There are numerous Tai-Kadai (TK)-speaking populations, but their detailed evolutionary history and biological adaptations are still unclear.ResultsHere, we genotyped genome-wide SNP data of 77 unrelated TK-speaking Zhuang and Dong individuals from the Yungui Plateau and explored their detailed admixture history and adaptive features using clustering patterns, allele frequency differentiation and sharing haplotype patterns. TK-speaking Zhuang and Dong people in Guizhou are closely related to geographically close TK and Hmong-Mien (HM)-speaking populations. Besides, we identified that Guizhou TK-speaking people have a close genetic relationship with Austronesian (AN)-speaking Atayal and Paiwan people, which is supported by the common origin of the ancient Baiyue tribe. We additionally found subtle genetic differences among the newly studied TK people and previously reported Dais via the fine-scale genetic substructure analysis based on the shared haplotype chunks. Finally, we identified specific selection candidate signatures associated with several essential human immune systems and neurological disorders, which could provide evolutionary evidence for the allele frequency distribution pattern of genetic risk loci.ConclusionsOur comprehensive genetic characterization of TK people suggested the strong genetic affinity within TK groups and extensive gene flow with geographically close HM and Han people. We also provided genetic evidence that supported the common origin hypothesis of TK and AN people. The best-fitted admixture models further suggested that ancestral sources from northern millet farmers and southern inland and coastal people contributed to the formation of the gene pool of the Zhuang and Dong people."

基金机构："Guizhou Scientific Support Project, Qian Science Support (2022) General [[2020]018]; Doctoral Foundation of Guizhou Medical University [280]"

基金资助正文："This study was supported by the Guizhou Scientific Support Project, Qian Science Support (2022) General 280 and the Doctoral Foundation of Guizhou Medical University [2020]018."