Metformin-based carbon dots based on biguanide functional groups for simultaneous chelation of copper ions and inhibitable colorectal cancer therapy

作者全名："Yu, Lidong; Wang, Yi; Li, Kai; Li, Xueting; He, Mingyue; Chen, Ce; Li, Fangshun; Liang, Bing; Li, Li; Gu, Ning; Liu, Zhiguo; Li, Bingsheng; Wang, Guixue; Fan, Jianglin"

作者地址："[Yu, Lidong; Li, Xueting; He, Mingyue; Chen, Ce; Li, Fangshun; Liang, Bing; Li, Li; Gu, Ning] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China; [Yu, Lidong; Liu, Zhiguo] Harbin Inst Technol, Sch Phys, Harbin 150080, Peoples R China; [Wang, Yi] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Li, Kai] Harbin Inst Technol, Sch Med & Hlth, Harbin 150080, Peoples R China; [Li, Bingsheng] Northeast Normal Univ, Key Lab UV Light Emitting Mat & Technol, Minist Educ, Changchun 130024, Peoples R China; [Wang, Guixue] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants,Minist, Chongqing 400030, Peoples R China; [Fan, Jianglin] Wuyi Univ, Southern China Inst Large Anim Models Biomed, Sch Biotechnol & Hlth Sci, Guangdong Prov Key Lab, Jiangmen 529000, Peoples R China"

通信作者："Li, L (通讯作者)，Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China."

来源：CARBON

ESI学科分类：CHEMISTRY

WOS号：WOS:001008359300001

JCR分区：Q1

影响因子：10.5

年份：2023

卷号：212

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Colorectal cancer; Metformin-based carbon dots; Biguanide functional groups; Copper chelating

摘要："Colorectal cancer (CRC) is the most common malignancy-related cause of death worldwide. The prognosis of CRC patients is strongly correlated with elevated plasma copper. The quantitative detection of plasma copper is highly essential for the field of biomedicine, and our hypothesis was that plasma copper may be a therapeutic target for treating CRC. Here, we developed metformin-based carbon dots (MFCDs). MFCDs have strong photo-luminescence at 460 nm, which is quenched by Cu2+. Cu2+ concentration and the fluorescence emission intensity of MFCDs are significantly associated (linear range of 0.5-40 mu M with a detection limit of 0.30 mu M). Additionally, administration of MFCDs significantly inhibited the growth of CRC xenografts in mice caused by the existence of biguanide functional groups. MFCDs treatment led to the increase of reactive oxygen species and subsequent DNA damage and cell cycle arrest. This study showed that the biguanide functional groups of MFCDs chelate with Cu2+, resulting in the reduction of Cu/Zn-superoxide dismutase and glutathione, which eventually reduces antioxidant capacity and ultimately induces cell apoptosis. These results indicate that MFCDs provide a novel approach for anticancer therapy."

基金机构："National Key Technologies Research and Development Program of China [2019YFA0705202, 2022YFA1105403]; National Natural Science Foundation of China [62274027, 31701296, 81941001]; Guangdong Province [2020KCXTD038]; Guangdong Province Key Program of Discipline [2021ZDJS091]; Chongqing Natural Science Foundation [cstc2019jcyj-zdxmX0028]"

基金资助正文："This work was supported by the National Key Technologies Research and Development Program of China under grant number: 2019YFA0705202 and 2022YFA1105403; the National Natural Science Foundation of China (62274027, 31701296 and 81941001) ; Innovation team program supported by Guangdong Province (2020KCXTD038) ; the Guangdong Province Key Program of Discipline (2021ZDJS091) ; the Chongqing Natural Science Foundation (cstc2019jcyj-zdxmX0028) ."