Nutrition impact symptoms in head and neck cancer during radiotherapy: a longitudinal study

作者全名："Li, Minmin; Nutting, Chris; Zhang, Tao; Gou, Qitao; Liu, Ting"

作者地址："[Li, Minmin; Zhang, Tao; Gou, Qitao; Liu, Ting] Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, Chongqing, Peoples R China; [Nutting, Chris] Royal Marsden Hosp, Head & Neck Unit, London, England; [Nutting, Chris] Inst Canc Res, Div Radiotherapy & Imaging, London, England; [Liu, Ting] Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, Youyi Rd 1, Chongqing 400016, Peoples R China"

通信作者："Liu, T (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, Youyi Rd 1, Chongqing 400016, Peoples R China."

来源：ACTA OTO-LARYNGOLOGICA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001008620500001

JCR分区：Q3

影响因子：1.2

年份：2023

卷号：143

期号：6

开始页：499

结束页：506

文献类型：Article

关键词：Nutrition impact symptoms; malnutrition; head and neck cancer; radiotherapy; tumor response

摘要："BackgroundPatients with head and neck cancer (HNC) receiving radiotherapy (RT) are at a high risk of weight loss (WL) due to a variety of nutrition impact symptoms (NISs).ObjectiveThis prospective observational study aimed to investigate the consecutive changes of NIS during RT and analyzed its impact on body weight.Materials and methodsThe Head and Neck patient Symptom Checklist was adopted to evaluate NIS. NIS, body weight, hemoglobin and lymphocyte of 94 participants were assessed at four time points during RT and the treatment outcomes were assessed at the time of 12 months after the completion of RT. Generalised estimation equations (GEEs) and Kendall's tau-b were used for statistical analysis.ResultsOur study found that pain, taste changes and dry mouth were the most common NIS, reported by >90% of patients and had higher interference scores (more than 85% >2) at the end of RT. The average WL was 4.22 +/- 3.59 kg after treatment, and more than two-thirds of patients (67.02%, 64/94) experienced significant WL of >5%. Lack of energy, vomiting and taste changes impacted WL significantly (p < .05). Taste changes were also associated with hemoglobin and lymphocyte reduction (p = .018, p < .001). WL correlated negatively with tumor response (p = .031).Conclusions and significanceIn patients with HNC, taste changes, pain, dry mouth and vomiting were seen. Nutritional intervention applied as early as the first 10 days of RT could help to change the nutrition status and improve the clinical outcomes."

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