N6-methyladenosine-mediated gene regulation and therapeutic implications

作者全名："Liu, Yujiao; Yang, Dan; Liu, Tao; Chen, Jianjun; Yu, Jianhua; Yi, Ping"

作者地址："[Liu, Yujiao; Yang, Dan; Liu, Tao; Yu, Jianhua; Yi, Ping] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Chongqing 401120, Peoples R China; [Chen, Jianjun] City of Hope, Beckman Res Inst, Dept Syst Biol, Los Angeles, CA 91010 USA; [Yu, Jianhua] City Hope Natl Med Ctr, Hematol Malignancies Res Inst, Los Angeles, CA 91010 USA; [Yu, Jianhua] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Los Angeles, CA 91010 USA"

通信作者："Yu, JH; Yi, P (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Chongqing 401120, Peoples R China.; Yu, JH (通讯作者)，City Hope Natl Med Ctr, Hematol Malignancies Res Inst, Los Angeles, CA 91010 USA.; Yu, JH (通讯作者)，City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Los Angeles, CA 91010 USA."

来源：TRENDS IN MOLECULAR MEDICINE

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001009517900001

JCR分区：Q1

影响因子：12.8

年份：2023

卷号：29

期号：6

开始页：454

结束页：467

文献类型：Review

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摘要："N6-methyladenosine (m6A) RNA methylation is the most abundant form of mRNA modification in eukaryotes and is at the front line of biological and biomedical re-search. This dynamic and reversible m6A RNA modification determines the fates of modified RNA molecules at the post-transcriptional level, affecting almost all important biological processes. Notably, m6A is also involved in chromatin and transcriptional regulation, while m6A dysregulation is implicated in various dis-eases. Here, we review current knowledge of post-transcriptional and transcrip-tional regulatory mechanisms involving m6A modification. We also discuss their involvement in the occurrence and development of diseases, including cancer, as well as potential theranostic targets, in hope of facilitating the translation of preclinical findings to the clinic."

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