A Chinese prospective multicenter cohort study evaluating EUS-guided drainage of pancreatic fluid collections using the Hot AXIOS system

作者全名："Li, Peng; Zhang, Zheng; Wang, Sheng; Jin, Zhendong; Du, Yiqi; Yang, Aiming; Feng, Yunlu; Zou, Xiaoping; Wang, Lei; Wang, Xiaoyan; Tian, Li; Zhou, Pinghong; Zhang, Yiqun; Liu, Jun; Ding, Zhen; Zhang, Junwen; Yang, Jian; Sun, Siyu; Zhang, Shutian"

作者地址："[Li, Peng; Zhang, Zheng; Zhang, Shutian] Capital Med Univ, Beijing Friendship Hosp, Dept Gastroenterol, Beijing, Peoples R China; [Wang, Sheng; Sun, Siyu] China Med Univ, Shengjing Hosp, Dept Gastroenterol, Shenyang, Liaoning, Peoples R China; [Jin, Zhendong; Du, Yiqi] Second Mil Med Univ, Naval Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai, Peoples R China; [Yang, Aiming; Feng, Yunlu] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing, Peoples R China; [Zou, Xiaoping; Wang, Lei] Nanjing Univ, Affiliated Drum Tower Hosp, Med Sch, Dept Gastroenterol, Nanjing, Jiangsu, Peoples R China; [Wang, Xiaoyan] Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Hunan, Peoples R China; [Zhang, Yiqun] Fudan Univ, Zhongshan Hosp, Endoscopy Ctr, Shanghai, Peoples R China; [Liu, Jun; Ding, Zhen] Huazhong Univ Sci & Technol, Wuhan Union Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan, Hubei, Peoples R China; [Zhang, Junwen; Yang, Jian] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Chongqing, Peoples R China; [Sun, Siyu] China Med Univ, Shengjing Hosp, Dept Gastroenterol, Shenyang 110004, Liaoning, Peoples R China; [Zhang, Shutian] Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, Beijing Digest Dis Ctr,Beijing Key Lab Precancerou, Beijing 100050, Peoples R China"

通信作者："Sun, SY (通讯作者)，China Med Univ, Shengjing Hosp, Dept Gastroenterol, Shenyang 110004, Liaoning, Peoples R China.; Zhang, ST (通讯作者)，Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, Beijing Digest Dis Ctr,Beijing Key Lab Precancerou, Beijing 100050, Peoples R China."

来源：ENDOSCOPIC ULTRASOUND

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001009915800009

JCR分区：Q1

影响因子：4.4

年份：2023

卷号：12

期号：2

开始页：259

结束页：265

文献类型：Article

关键词：EUS; evaluation; Hot AXIOS system; pancreatic fluid collection drainage

摘要："Background and Objectives: The Hot AXIOS system, which features a cautery-enhanced lumen-apposing metal stent, facilitates EUS-guided transmural drainage of pancreatic fluid collection (PFC). We aimed to evaluate the safety and efficacy of stents in a multicenter Chinese cohort. Patients and Methods: Thirty patients from nine centers with a single pancreatic pseudocyst (PP) or walled-off necrosis (WON) who underwent EUS-guided transgastric or transduodenal drainage with the novel stent were prospectively enrolled. Results: We included 15 (50%) patients with PPs and 15 (50%) with WONs. The mean diameter of the PFCs was 11.06 +/- 3.56 cm. Stent placement was technically successful in all patients (100%), whereas clinical success was achieved in 93.3% of patients (28/30). Clinical success was defined as the alleviation of clinical symptoms combined with at least a 50% reduction in PFC diameter within 60 days after surgery. 73.3% (22/30) of AXIOS stents were removed after reaching clinical success in the 1st month of follow-up. A total of 14 (46.7%) PFC-associated infections occurred (4 pre- and 10 postoperation), which recovered within 1 week after treatment. Other complications included three (10%) partially or fully blocked stents and two (6.7%) stent migrations. Regarding the fully opened stent without blocking, complete remission of PFCs within 1 month was independently predicted by a previous pancreatitis attack > 6 months prior (adjusted odds ratio: 11.143; 95% confidence interval: 1.108-112.012; P = 0.041). Conclusion: EUS-guided drainage of PFCs using the Hot AXIOS system is safe and efficient. Regarding completely patent stents, a previous pancreatitis attack > 6 months prior predicts a greater chance of achieving 100% remission of PFCs within 1 month of AXIOS treatment."

基金机构：Boston Scientific Corporation

基金资助正文：The study was funded by Boston Scientific Corporation