Different brain functional network abnormalities between attention-deficit/hyperactivity disorder youth with and without familial risk for bipolar disorder

作者全名："Qin, Kun; Lei, Du; Zhu, Ziyu; Li, Wenbin; Tallman, Maxwell J.; Rodrigo Patino, L.; Fleck, David E.; Aghera, Veronica; Gong, Qiyong; Sweeney, John A.; McNamara, Robert K.; DelBello, Melissa P."

作者地址："[Qin, Kun; Zhu, Ziyu; Gong, Qiyong; Sweeney, John A.] Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, West China Hosp, Chengdu 610041, Sichuan, Peoples R China; [Qin, Kun; Zhu, Ziyu; Tallman, Maxwell J.; Rodrigo Patino, L.; Fleck, David E.; Aghera, Veronica; Sweeney, John A.; McNamara, Robert K.; DelBello, Melissa P.] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Coll Med, Cincinnati, OH 45219 USA; [Qin, Kun] Hubei Univ Med, Taihe Hosp, Dept Radiol, Shiyan 442000, Hubei, Peoples R China; [Lei, Du] Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China; [Li, Wenbin] Zhengzhou Univ, Affiliated Hosp 1, Dept Magnet Resonance Imaging, Zhengzhou, Henan, Peoples R China"

通信作者："Gong, QY (通讯作者)，Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, West China Hosp, Chengdu 610041, Sichuan, Peoples R China.; Lei, D (通讯作者)，Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China."

来源：EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001010660800001

JCR分区：Q1

影响因子：6

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：fMRI; Graph theory; Bipolar disorder; Genetic risk; ADHD; Functional connectivity

摘要："Attention-deficit/hyperactivity disorder (ADHD) commonly precedes the initial onset of mania in youth with familial risk for bipolar disorder (BD). Although ADHD youth with and without BD familial risk exhibit different clinical features, associated neuropathophysiological mechanisms remain poorly understood. This study aimed to identify brain functional network abnormalities associated with ADHD in youth with and without familial risk for BD. Resting-state functional magnetic resonance imaging scans were acquired from 37 ADHD youth with a family history of BD (high-risk), 45 ADHD youth without a family history of BD (low-risk), and 32 healthy controls (HC). Individual whole-brain functional networks were constructed, and graph theory analysis was applied to estimate network topological metrics. Topological metrics, including network efficiency, small-worldness and nodal centrality, were compared across groups, and associations between topological metrics and clinical ratings were evaluated. Compared to HC, low-risk ADHD youth exhibited weaker global integration (i.e., decreased global efficiency and increased characteristic path length), while high-risk ADHD youth showed a disruption of localized network components with decreased frontoparietal and frontolimbic connectivity. Common topological deficits were observed in the medial superior frontal gyrus between low- and high-risk ADHD. Distinct network deficits were found in the inferior parietal lobule and corticostriatal circuitry. Associations between global topological metrics and externalizing symptoms differed significantly between the two ADHD groups. Different patterns of functional network topological abnormalities were found in high- as compared to low-risk ADHD, suggesting that ADHD in youth with BD familial risk may represent a phenotype that is different from ADHD alone."

基金机构：NIMH [R01 MH097818]; National Natural Science Foundation of China [81621003]; Chongqing Talents Exceptional Young Talents Project

基金资助正文："This study was supported by NIMH Grant R01 MH097818 to M.P.D and R.K.M (Co-PIs) and the National Natural Science Foundation of China (Q.G., Grant No. 81621003). Du Lei was supported by Chongqing Talents Exceptional Young Talents Project."