Constipation in multiple system atrophy: a pilot study in Chinese patients

作者全名："Chen, Yalan; Huang, Hongyan; Zhang, Peng; Xu, Yanming; Chen, Yangmei"

作者地址："[Chen, Yalan; Zhang, Peng; Chen, Yangmei] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China; [Huang, Hongyan; Xu, Yanming] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China"

通信作者："Chen, YM (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China.; Xu, YM (通讯作者)，Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China."

来源：FRONTIERS IN NEUROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001010817600001

JCR分区：Q2

影响因子：2.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：multiple system atrophy; constipation; prevalence; non-motor symptom; ROME III criteria

摘要："ObjectiveThis study aimed to investigate the prevalence and clinical characteristics of subjective constipation in Chinese patients with multiple system atrophy (MSA), as well as the timing of constipation onset relative to the occurrence of motor symptoms. MethodsA total of 200 patients who were consecutively admitted to two large Chinese hospitals from February 2016 to June 2021 and subsequently diagnosed with probable MSA were enrolled in this cross-sectional study. Demographic and constipation-related clinical data were collected, and motor and non-motor symptoms were assessed using various scales and questionnaires. Subjective constipation was defined using ROME III criteria. ResultsThe frequency of constipation was 53.5, 59.7, and 39.3% in MSA, MSA with predominately parkinsonism (MSA-P), and MSA with predominately cerebellar ataxia (MSA-C), respectively. MSA-P subtype and high total UMSARS scores were associated with constipation in MSA. Similarly, the high total UMSARS scores were associated with constipation in MSA-P and MSA-C patients. Among the 107 patients with constipation, 59.8% began experiencing it before the onset of motor symptoms, and the interval between constipation and occurrence of motor symptoms was significantly longer in these patients than in those who experienced constipation after onset of motor symptoms. ConclusionConstipation is a highly prevalent non-motor symptom in MSA and more often occurs before the onset of motor symptoms. The results of this study may help guide future research into MSA pathogenesis in its earliest stages."

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