Effects of vitamin B12 deficiency on risk and outcome of ischemic stroke

作者全名："Zhou, Li; Song, Xiaosong; Wang, Jiani; Tan, Yongjun; Yang, Qin"

作者地址："[Zhou, Li; Song, Xiaosong; Wang, Jiani; Tan, Yongjun; Yang, Qin] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China; [Song, Xiaosong] Ninth Peoples Hosp Chongqing, Dept Neurol, Chongqing, Peoples R China; [Yang, Qin] 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Yang, Q (通讯作者)，1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：CLINICAL BIOCHEMISTRY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001011461800001

JCR分区：Q2

影响因子：2.5

年份：2023

卷号：118

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Vitamin B 12 deficiency; Cobalamin deficiency; Ischemic stroke; Homocysteinemia; Intrinsic factor; Pernicious anemia

摘要："Ischemic stroke is the most prevalent form of stroke and has a high incidence in older adults, characterized by high morbidity, mortality, disability, and recurrence rate. Vitamin B12 deficiency is prevalent in the elderly and has been reported to be associated with ischemic stroke. The mechanisms maybe include the disorder of methylation metabolism, accumulation of toxic metabolites, immune dysfunction, affecting gut microbial composition and gut-brain immune homeostasis, and toxic stress responses to the brain. Vitamin B12 deficiency may lead to cerebral artery atherosclerosis, change myelination, influence the metabolism and transmission between nerve tissue, and ultimately causes the occurrence and development of ischemic stroke. This paper reviews the correlation between vitamin B12 deficiency and ischemic stroke, looking forward to improving clinicians' understanding and providing new therapeutic directions for ischemic stroke."

基金机构："National Natural Science Founda-tion of China [82171456, 81971229]"

基金资助正文："Funding This study was supported by the National Natural Science Founda-tion of China (grant 82171456, grant 81971229, to Qin Yang) ."