"5-ALA-PDT induced ferroptosis in keloid fibroblasts via ROS, accompanied by downregulation of xCT, GPX4"

作者全名："Zhang, Jiheng; Liu, Lulu; Li, Xinying; Shen, Xiaoxiao; Yang, Guihong; Deng, Yumeng; Hu, Zhengwei; Zhang, Junbo; Lu, Yuangang"

作者地址："[Zhang, Jiheng; Liu, Lulu; Li, Xinying; Zhang, Junbo; Lu, Yuangang] Army Med Univ, Daping Hosp, Dept Plast & Cosmet Surg, Chongqing, Peoples R China; [Shen, Xiaoxiao] Chongqing Univ, Bioengn Coll, Chongqing, Peoples R China; [Yang, Guihong] Army Med Univ, Daping Hosp, Dept Dermatol, Chongqing, Peoples R China; [Deng, Yumeng] Chongqing Med Univ, Affiliated Hosp 3, Dept Dermatol, Chongqing, Peoples R China; [Hu, Zhengwei] Army Med Univ, Daping Hosp, Dept Urol, Chongqing, Peoples R China"

通信作者："Zhang, JB; Lu, YG (通讯作者)，Army Med Univ, Daping Hosp, Dept Plast & Cosmet Surg, Chongqing, Peoples R China."

来源：PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001011644600001

JCR分区：Q2

影响因子：3.1

年份：2023

卷号：42

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Keloids; Fibroblast; PDT; Ferroptosis

摘要："Keloids display many cancerous properties, including uncontrolled and invasive growth, high rates of recurrence as well as similar bioenergetics. 5-aminolevulinic acid-based photodynamic therapy (5-ALA-PDT) is an effective treatment that performs cytotoxic effects by producing reactive oxygen species (ROS), which is linked to lipid peroxidation and ferroptosis. Herein, we explored underlying mechanisms of 5-ALA-PDT against keloids. We identified that 5-ALA-PDT led to elevated levels of ROS and lipid peroxidation in keloid fibroblasts, accompanied by downregulation of xCT and GPX4, which are associated with anti-oxidation effects and ferroptosis inhibition. These results may indicate that 5-ALA-PDT treatment increases ROS while inhibiting xCT and GPX4, thus pro-moting lipid peroxidation to induce ferroptosis in keloid fibroblasts."

基金机构：Innovative Training Program Foundation for the Talents by Daping Hospital [2019CXJSC034]; Chongqing Medical Scientific Research Proj-ect (Joint Project of Chongqing Health Commission and Science and Technology Bureau) [2023MSXM071]

基金资助正文：Funding This work was supported by the Innovative Training Program Foundation for the Talents by Daping Hospital under Grant [No.2019CXJSC034] and Chongqing Medical Scientific Research Proj-ect (Joint Project of Chongqing Health Commission and Science and Technology Bureau) [No.2023MSXM071] .