Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury

作者全名："Zhu, Ziyu; Huang, Xuekang; Du, Mengran; Wu, Chenrui; Fu, Jiayuanyuan; Tan, Weilin; Wu, Biying; Zhang, Jie; Liao, Z. B."

作者地址："[Zhu, Ziyu; Huang, Xuekang; Du, Mengran; Wu, Chenrui; Fu, Jiayuanyuan; Tan, Weilin; Wu, Biying; Zhang, Jie; Liao, Z. B.] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Liao, ZB (通讯作者)，Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：MOLECULAR PSYCHIATRY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001011694200001

JCR分区：Q1

影响因子：9.6

年份：2023

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期号：　

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结束页：　

文献类型：Review; Early Access

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摘要："Post-traumatic stress disorder (PTSD) is usually considered a psychiatric disorder upon emotional trauma. However, with the rising number of conflicts and traffic accidents around the world, the incidence of PTSD has skyrocketed along with traumatic brain injury (TBI), a complex neuropathological disease due to external physical force and is also the most common concurrent disease of PTSD. Recently, the overlap between PTSD and TBI is increasingly attracting attention, as it has the potential to stimulate the emergence of novel treatments for both conditions. Of note, treatments exploiting the microRNAs (miRNAs), a well-known class of small non-coding RNAs (ncRNAs), have rapidly gained momentum in many nervous system disorders, given the miRNAs' multitudinous and key regulatory role in various biological processes, including neural development and normal functioning of the nervous system. Currently, a wealth of studies has elucidated the similarities of PTSD and TBI in pathophysiology and symptoms; however, there is a dearth of discussion with respect to miRNAs in both PTSD and TBI. In this review, we summarize the recent available studies of miRNAs in PTSD and TBI and discuss and highlight promising miRNAs therapeutics for both conditions in the future."

基金机构：National Natural Science Foundation of China [81771355]; Natural Science Foundation of Chongqing Science and Technology Bureau [CSTC2015jcyjA10096]

基金资助正文：AcknowledgementsThis work was supported by the National Natural Science Foundation of China (No. 81771355) and the Natural Science Foundation of Chongqing Science and Technology Bureau (CSTC2015jcyjA10096).