Shear stress regulation of nanoparticle uptake in vascular endothelial cells

作者全名："Zhang, Hongping; Hu, Ziqiu; Wang, Jinxuan; Xu, Jianxiong; Wang, Xiangxiu; Zang, Guangchao; Qiu, Juhui; Wang, Guixue"

作者地址："[Zhang, Hongping; Hu, Ziqiu; Wang, Jinxuan; Xu, Jianxiong; Wang, Xiangxiu; Qiu, Juhui; Wang, Guixue] Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China; [Zang, Guangchao] Chongqing Med Univ, Lab Teaching & Management Ctr, Chongqing 400016, Peoples R China; [Qiu, Juhui; Wang, Guixue] JinFeng Lab, Chongqing 401329, Peoples R China"

通信作者："Qiu, JH; Wang, GX (通讯作者)，Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China.; Qiu, JH; Wang, GX (通讯作者)，JinFeng Lab, Chongqing 401329, Peoples R China."

来源：REGENERATIVE BIOMATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001012110000001

JCR分区：Q1

影响因子：5.6

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：shear stress; nanoparticle uptake; endothelial cell; clathrin; caveolin

摘要："Nanoparticles (NPs) hold tremendous targeting potential in cardiovascular disease and regenerative medicine, and exciting clinical applications are coming into light. Vascular endothelial cells (ECs) exposure to different magnitudes and patterns of shear stress (SS) generated by blood flow could engulf NPs in the blood. However, an unclear understanding of the role of SS on NP uptake is hindering the progress in improving the targeting of NP therapies. Here, the temporal and spatial distribution of SS in vascular ECs and the effect of different SS on NP uptake in ECs are highlighted. The mechanism of SS affecting NP uptake through regulating the cellular ROS level, endothelial glycocalyx and membrane fluidity is summarized, and the molecules containing clathrin and caveolin in the engulfment process are elucidated. SS targeting NPs are expected to overcome the current bottlenecks and change the field of targeting nanomedicine. This assessment on how SS affects the cell uptake of NPs and the marginalization of NPs in blood vessels could guide future research in cell biology and vascular targeting drugs."

基金机构："National Natural Science Foundation of China [12032007, 31971242]; Chongqing Science and Technology Bureau [cstc2019jcyj-zdxmX0028]; JinFeng Laboratory, Chongqing, China [jfkyjf202203001]"

基金资助正文："The work is supported by the National Natural Science Foundation of China (12032007, 31971242) to G.W., the Chongqing Science and Technology Bureau (cstc2019jcyj-zdxmX0028) to G.W. and JinFeng Laboratory, Chongqing, China (jfkyjf202203001) to G.W."