Programmed release of hydrogel microspheres via regulating the immune microenvironment to promotes bone repair

作者全名："Cai, Weiye; Xu, Xiaoping; Jiang, Yingcun; Cheng, Kang; Liu, Fei; Song, Chao; Guo, Daru; Hu, Zhenming; Liu, Zhihong; Liu, Zongchao"

作者地址："[Cai, Weiye; Cheng, Kang; Liu, Fei; Song, Chao; Guo, Daru; Liu, Zongchao] Southwest Med Univ, Dept Orthoped, Affiliated Hosp Tradit Chinese Med, Luzhou 646000, Sichuan, Peoples R China; [Xu, Xiaoping; Hu, Zhenming] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing 400042, Peoples R China; [Xu, Xiaoping] Chengdu Med Coll, Dept Orthoped, Affiliated Hosp 1, Chengdu 610500, Sichuan, Peoples R China; [Jiang, Yingcun] Southwest Med Univ, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China; [Liu, Zhihong] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Sch Med,Shanghai Key Lab Prevent &, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China; [Liu, Zongchao] Luzhou Longmatan Dist Peoples Hosp, Luzhou 646000, Sichuan, Peoples R China"

通信作者："Liu, ZC (通讯作者)，Southwest Med Univ, Dept Orthoped, Affiliated Hosp Tradit Chinese Med, Luzhou 646000, Sichuan, Peoples R China.; Hu, ZM (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing 400042, Peoples R China.; Liu, ZH (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Sch Med,Shanghai Key Lab Prevent &, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China."

来源：MATERIALS TODAY ADVANCES

ESI学科分类：　

WOS号：WOS:001012330400001

JCR分区：Q1

影响因子：8.1

年份：2023

卷号：18

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Hydrogel microspheres; Microfluidic; Osteogenesis; Programmed; Immune microenvironment

摘要："Bone tissue repair is influenced by the synergistic interaction between acute immune microenvironment and osteogenesis. In this study will be independently by film dispersion method and static loading shell polymers and resveratrol liposome preparation CS - Res @ Lipo (CRL) and microfluidic technology preparation of HAMA@HepMA hydrogel microspheres (MS) by condensation reaction of chemical grafting, and then the non-covalent binding site of the MS microsphere was used to skillfully bind BMP-2, construct procedural release of hydrogel microspheres (CRL @ BMP - 2 @ MS). CRL@BMP-2@MS inhibit the acute immune peak by rapidly releasing Res, in addition, the sustained liberation of BMP-2 synchronizes osteoimmunity and osteogenesis, thereby accelerating bone repair. The results showed that Res was released with an increased cumulative rate of 72.4 & PLUSMN; 3.6% in the first 24 h, TNF-a and IL-1b levels were significantly decreased by 4.27 times and 3.65 times as compared to the control group, respectively. Furthermore, continuous release of approximately 40.26 & PLUSMN; 6.8% of BMP-2 occurred within the first 72 h, CRL@BMP-2@MS microspheres significantly increased osteogenic activity compared with the control group by 2.98 and 2.82 times, respectively. In conclusion, the programmed CRL@BMP-2@MS constructed in this study can realize the programmed synergistic linkage of immunity and osteogenesis, dynamically regulate bone repair, and the treatment of clinical bone repair will be based on a new strategy for diagnosis and treatment.& COPY; 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."

基金机构：Sichuan Science and Technology Department Project Development Project [22ZDYF512]; Program for Special project of Traditional Chinese Medicine scientific research of Sichuan Science and Traditional Chinese Medicine Administration [2020LC0228]; Program for Luzhou Municipal People's Government-Southwest Medical University science and technology strategic cooperation climbing project [2021LZXNYD-D02]; National Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0792]

基金资助正文："The present study was supported in part by research grants from the Project Supported by the Sichuan Science and Technology Department Project Development Project (nos. 22ZDYF512) , the Program for Special project of Traditional Chinese Medicine scientific research of Sichuan Science and Traditional Chinese Medicine Administration (nos. 2020LC0228) , and the Program for Luzhou Municipal People's Government-Southwest Medical University science and technology strategic cooperation climbing project (nos. 2021LZXNYD-D02) . The National Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0792) ."