Low-fat dairy consumption and the risk of lung cancer: A large prospective cohort study

作者全名："Zhu, Zhiyong; Peng, Linglong; Zhou, He; Gu, Haitao; Tang, Yunhao; Zhou, Zhihang; Xiang, Ling; Wang, Yaxu"

作者地址："[Zhu, Zhiyong; Peng, Linglong; Gu, Haitao; Tang, Yunhao; Wang, Yaxu] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Zhou, He] Univ Oxford, Lab Canc Biol, Dept Oncol, Oxford, England; [Zhou, He] North Sichuan Med Coll, Dept Gastrointestinal Surg 2, Affiliated Hosp, Nanchong, Peoples R China; [Zhou, Zhihang] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 2, Chongqing, Peoples R China; [Xiang, Ling] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Wang, YX (通讯作者)，Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：CANCER MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001012679800001

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Cox regression analysis; low-fat dairy; lung cancer; PLCO trial

摘要："Background: Despite the possible contribution of dairy products to the development or prevention of cancers, there is a lack of epidemiological evidence linking low-fat dairy consumption to the risk of developing lung cancer. This research was conducted to fill this knowledge gap.Methods: The data for this research were collected from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. The Cox proportional risk model was employed to evaluate the link between low-fat dairy consumption and the risk of developing lung cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) were measured in both unadjusted and adjusted models. A series of predefined subgroup analyses were performed to identify potential effect modifiers, and several sensitivity analyses were conducted to assess the stability of the findings.Results: The study included data from 98,459 individuals. During a total of 869,807.9 follow-up person-years, 1642 cases of lung cancer were observed, with an incidence of 0.189 cases for every 100 person-years. In the fully adjusted model, participants in the highest quartile of low-fat dairy consumption had a significantly decreased risk of lung cancer compared to the ones in the lowest quartile (HRquartile 4 vs. 1: 0.769, 95% CI: 0.664, 0.891, p(trend) = 0.005). The restricted cubic spline plot revealed an inverse nonlinear dose-response relationship between low-fat dairy consumption and lung cancer risk (p(nonlinearity) = 0.008). Subgroup analyses demonstrated that the inverse association was stronger among participants with higher daily caloric intake (p(interaction) = 0.031). Various sensitivity analyses produced consistent results.Conclusion: Consuming more low-fat dairy products is significantly linked to a reduced risk of developing lung cancer, indicating that an appropriate increase in the use of low-fat dairy products may help prevent lung cancer."

基金机构："Chongqing Science and Technology Commission [CSTB2022NSCQ-MSX1005, cstc2021jcyj-msxmX0112, cstc2021jcyj-msxmX0153]"

基金资助正文："Chongqing Science and Technology Commission, Grant/Award Number: CSTB2022NSCQ-MSX1005, cstc2021jcyj-msxmX0112 and cstc2021jcyj-msxmX0153"