The independent prediction study of the effect of heart-type fatty acid binding protein on the severity and long-term cardiac function in Covid-19 patients

作者全名："Yin, Li; Wang, Hailong; Shao, Jiang; Mou, Huaming; Su, Li"

作者地址："[Yin, Li; Su, Li] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing, Peoples R China; [Wang, Hailong; Shao, Jiang; Mou, Huaming] Chongqing Univ, Heart Ctr, Gorges Hosp 3, Dept Cardiol, Chongqing, Peoples R China"

通信作者："Su, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing, Peoples R China."

来源：JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001012745700020

JCR分区：Q3

影响因子：0.8

年份：2023

卷号：73

期号：6

开始页：1272

结束页：1274

文献类型：Article

关键词：Heart-type fatty acid binding protein (HFABP); Covid-19; severity; cardiac function

摘要："The study was conducted to assess the predictive ability of the heart-type fatty acid binding protein (HFABP) on the severity and long-term cardiac function of Covid-19 infected persons. In the case of negative HsTn-T, we determined whether HFABP was related to the severity of Covid-19 or it was the long-term impact of cardiac function. Chi-square test and t-test were used to evaluate whether HFABP level was an independent predictor of myocardial injury and whether it was related to the severity of Covid-19 and the long-term impact of cardiac function. Among the 20 patients in each of the two groups (mild and severe), 27.5% of all had elevated HFABP. Two were HFABP positive in the mild group, and nine were HFABP positive in the severe group, with a significant difference between the two groups (P=0.013). The mean serum level of HFABP in the mild group was 3.96 & PLUSMN;1.80, compared with 6.70 & PLUSMN;3.77 in the severe group, with a significant difference between the two groups (P=0.003). In addition, after two years of follow-up, there was a statistically significant difference in the changes of cardiac function between the HFABP-positive group and the HFABP-negative group (P=0.037). These data indicate function in Covid-19 patients."

基金机构：Chongqing Science and Health Joint Medical Research Project [2020FYYX203]

基金资助正文：Source of Funding: The study was supported by the Chongqing Science and Health Joint Medical Research Project (2020FYYX203) .