Transcriptomics and magnetic resonance imaging in major psychiatric disorders

作者全名："Fan, Jing-Wen; Gu, Yue-Wen; Wang, Dong-Bao; Liu, Xiao-Fan; Zhao, Shu-Wan; Li, Xiao; Li, Baojuan; Yin, Hong; Wu, Wen-Jun; Cui, Long-Biao"

作者地址："[Fan, Jing-Wen; Gu, Yue-Wen; Liu, Xiao-Fan; Zhao, Shu-Wan; Cui, Long-Biao] Fourth Mil Med Univ, Dept Clin Psychol, Xian, Peoples R China; [Fan, Jing-Wen; Gu, Yue-Wen; Zhao, Shu-Wan; Yin, Hong] Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian, Peoples R China; [Wang, Dong-Bao; Cui, Long-Biao] Fourth Mil Med Univ, Schizophrenia Imaging Lab, Xian, Peoples R China; [Li, Xiao] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Baojuan] Fourth Mil Med Univ, Sch Biomed Engn, Xian, Peoples R China; [Yin, Hong] Xian Fourth Hosp, Xian Peoples Hosp, Dept Radiol, Xian, Peoples R China; [Wu, Wen-Jun] Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Peoples R China; [Cui, Long-Biao] Xi An Jiao Tong Univ, Dept Radiol, Affiliated Hosp 1, Xian, Peoples R China"

通信作者："Cui, LB (通讯作者)，Fourth Mil Med Univ, Dept Clin Psychol, Xian, Peoples R China.; Yin, H (通讯作者)，Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian, Peoples R China.; Cui, LB (通讯作者)，Fourth Mil Med Univ, Schizophrenia Imaging Lab, Xian, Peoples R China.; Yin, H (通讯作者)，Xian Fourth Hosp, Xian Peoples Hosp, Dept Radiol, Xian, Peoples R China.; Wu, WJ (通讯作者)，Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Peoples R China.; Cui, LB (通讯作者)，Xi An Jiao Tong Univ, Dept Radiol, Affiliated Hosp 1, Xian, Peoples R China."

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001013209500001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：MRI; transcriptomics; major depressive disorder; bipolar disorder; schizophrenia

摘要："Major psychiatric disorders create a significant public health burden, and mental disorders such as major depressive disorder, bipolar disorder, and schizophrenia are major contributors to the national disease burden. The search for biomarkers has been a leading endeavor in the field of biological psychiatry in recent decades. And the application of cross-scale and multi-omics approaches combining genes and imaging in major psychiatric studies has facilitated the elucidation of gene-related pathogenesis and the exploration of potential biomarkers. In this article, we summarize the results of using combined transcriptomics and magnetic resonance imaging to understand structural and functional brain changes associated with major psychiatric disorders in the last decade, demonstrating the neurobiological mechanisms of genetically related structural and functional brain alterations in multiple directions, and providing new avenues for the development of quantifiable objective biomarkers, as well as clinical diagnostic and prognostic indicators."

基金机构：China Postdoctoral Science Foundation [2020M683739]; Fourth Military Medical University [2021JSTS30]; Youth Project of General Items for Shaanxi Natural Science Foundation [2022JQ-908]; National Natural Science Foundation of China [61976248]

基金资助正文："Funding This work was supported by the Project funded by China Postdoctoral Science Foundation, grant number 2020M683739, the Fourth Military Medical University, grant number 2021JSTS30, Youth Project of General Items for Shaanxi Natural Science Foundation, grant number 2022JQ-908, and National Natural Science Foundation of China, grant number 61976248."