Bryostatin-1: a promising compound for neurological disorders

作者全名："Tian, Zhen; Lu, Xin-Tong; Jiang, Xun; Tian, Jiao"

作者地址："[Tian, Zhen; Lu, Xin-Tong] Southwest Univ, Coll Pharmaceut Sci, Chongqing, Peoples R China; [Jiang, Xun] Fourth Mil Med Univ, Dept Pediat, Tangdu Hosp, Xian, Peoples R China; [Tian, Jiao] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Infect,Batch of Key Disciplines Publ Hlth Cho, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China"

通信作者："Jiang, X (通讯作者)，Fourth Mil Med Univ, Dept Pediat, Tangdu Hosp, Xian, Peoples R China.; Tian, J (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Infect,Batch of Key Disciplines Publ Hlth Cho, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001013674900001

JCR分区：Q1

影响因子：4.4

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Alzheimer's disease; Bryostatin-1; fragile X syndrome; multiple sclerosis; protein kinase C; stroke; traumatic brain injury

摘要："The central nervous system (CNS) is the most complex system in human body, and there is often a lack of effective treatment strategies for the disorders related with CNS. Natural compounds with multiple pharmacological activities may offer better options because they have broad cellular targets and potentially produce synergic and integrative effects. Bryostatin-1 is one of such promising compounds, a macrolide separated from marine invertebrates. Bryostatin-1 has been shown to produce various biological activities through binding with protein kinase C (PKC). In this review, we mainly summarize the pharmacological effects of bryostatin-1 in the treatment of multiple neurological diseases in preclinical studies and clinical trials. Bryostatin-1 is shown to have great therapeutic potential for Alzheimer's disease, multiple sclerosis, fragile X syndrome, stroke, traumatic brain injury, and depression. It exhibits significant rescuing effects on the deficits of spatial learning, cognitive function, memory and other neurological functions caused by diseases, producing good neuroprotective effects. The promising neuropharmacological activities of bryostatin-1 suggest that it is a potential candidate for the treatment of related neurological disorders although there are still some issues needed to be addressed before its application in clinic."

基金机构：National Natural Science Foundation of China [81801329]; Chongqing Natural Science Foundation [cstc2021jcyj-msxmX0610]; Fundamental Research Funds for the Central Universities [SWU-KQ22018]; Science and technology research project of Chongqing Education Commission [KJQN202100213]

基金资助正文："Funding This study is supported by National Natural Science Foundation of China (No. 81801329), Chongqing Natural Science Foundation (No. cstc2021jcyj-msxmX0610), Fundamental Research Funds for the Central Universities (No. SWU-KQ22018), Science and technology research project of Chongqing Education Commission (No. KJQN202100213)."