Constructing electrochemical sensor using molecular-imprinted polysaccharide for rapid identification and determination of L-tryptophan in diet

作者全名："Li, Yan-Jun; Yang, Li-Li; Ni, Li; Xiong, Jia-Min; He, Jia-Yuan; Zhou, Lian-Di; Luo, Ling; Zhang, Qi-Hui; Yuan, Chun-Su"

作者地址："[Li, Yan-Jun; Yang, Li-Li; Ni, Li; Xiong, Jia-Min; He, Jia-Yuan; Zhang, Qi-Hui] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400044, Peoples R China; [Zhou, Lian-Di] Chongqing Med Univ, Basic Med Coll, Chongqing 400016, Peoples R China; [Luo, Ling] Chongqing Univ, Chongqing Canc Inst, Canc Hosp, Hanyu Rd 181, Chongqing 400030, Peoples R China; [Zhang, Qi-Hui; Yuan, Chun-Su] Univ Chicago, Tang Ctr Herbal Med Res, Chicago, IL 60637 USA; [Zhang, Qi-Hui; Yuan, Chun-Su] Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA"

通信作者："Zhang, QH (通讯作者)，Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400044, Peoples R China.; Zhou, LD (通讯作者)，Chongqing Med Univ, Basic Med Coll, Chongqing 400016, Peoples R China.; Luo, L (通讯作者)，Chongqing Univ, Chongqing Canc Inst, Canc Hosp, Hanyu Rd 181, Chongqing 400030, Peoples R China.; Zhang, QH (通讯作者)，Univ Chicago, Tang Ctr Herbal Med Res, Chicago, IL 60637 USA.; Zhang, QH (通讯作者)，Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA."

来源：FOOD CHEMISTRY

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001015324700001

JCR分区：Q1

影响因子：8.5

年份：2023

卷号：425

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：L -tryptophan; Chirality; Electrochemical sensor; Bifunctional monomers; Molecularly imprinted polymer

摘要："An imbalance of L-tryptophan (L-Trp), a basic component of a healthy diet, is harmful to human health. Traditional methods for detecting L-Trp have many limitations. To correct a deficiency or excess of L-Trp in human diets, it is necessary to develop a novel method that is rapid, low-cost, and high-sensitivity. Herein, a molecularly imprinted polysaccharide electrochemical sensor termed MIP/CS/MWCNTs/GCE (molecularly imprinted polymer/chitosan/multiwalled carbon nanotubes/glassy carbon electrode) targeting L-Trp was first constructed on a glassy carbon electrode, which was modified with multiwalled carbon nanotubes and chitosan using bifunctional monomers. The MIP/CS/MWCNTs/GCE obtained a wide linear range (1-300 & mu;M) for detecting L-Trp and accurately detected the proportion of L-Trp in mixtures of Trp enantiomers. In milk samples, the spiked recoveries of L-Trp were 86.50 to 99.65%. The MIP/CS/MWCNTs/GCE electrochemical sensor possessed good recognition and detection performance for L-Trp and has promising potential for practical application."

基金机构："National Natural Science Foundation of China [81973451]; Fundamental and Frontier Research Fund of Chongqing [cstc2018jcyjAX0661, cstc2019jsyj- yzysbAX0020]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-K201800103]; Fundamental Research Funds for the Central Universities [2019CDYGYB027]; Graduate Research and Innovation Foundation of Chongqing [CYS18033]; Venture amp; Innovation Support Program for Chongqing Overseas Returnees; Tang Foundations"

基金资助正文："This work was financially supported by National Natural Science Foundation of China [No. 81973451] ; Fundamental and Frontier Research Fund of Chongqing [Nos. cstc2018jcyjAX0661, cstc2019jsyj- yzysbAX0020] ; the Science and Technology Research Program of Chongqing Municipal Education Commission [No. KJZD-K201800103] ; Fundamental Research Funds for the Central Universities [No. 2019CDYGYB027] ; Graduate Research and Innovation Foundation of Chongqing [No. CYS18033] ; Venture & Innovation Support Program for Chongqing Overseas Returnees, and Tang Foundations."