Early life growth and developmental trajectory in children with biliary atresia undergoing primary liver transplantation

作者全名："Fang, Heping; Li, Zehao; Xian, Ruoling; Yin, Yu; Wang, Juan; Guo, Hongling; Dai, Xiaoke; Zhang, Mingman; Hu, Yan; Li, Yingcun"

作者地址："[Fang, Heping; Xian, Ruoling; Yin, Yu; Wang, Juan; Hu, Yan] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Child Hlth Care, Chongqing Key Lab Pediat,Childrens Hosp ,Minist Ed, Chongqing, Peoples R China; [Li, Zehao; Guo, Hongling; Dai, Xiaoke; Zhang, Mingman; Li, Yingcun] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, Dept Hepatobiliary Surg,Childrens Hosp,Minist Edu, Chongqing, Peoples R China"

通信作者："Li, YC (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, Dept Hepatobiliary Surg,Childrens Hosp,Minist Edu, Chongqing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001016052900001

JCR分区：Q2

影响因子：2.1

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：biliary atresia (BA); primary liver transplantation (pLT); growth and development; early life; children

摘要："ObjectiveTo clarify the early growth and developmental characteristics of children with biliary atresia (BA) undergoing primary liver transplantation (pLT).MethodsA prospective cohort study, which specifically focused on BA-pLT children, was conducted after the diagnosis of BA by following the children at the time of pLT and 1, 3, 5, 7 months and 1 year after pLT for growth and developmental monitoring. The growth parameters were calculated according to the WHO standard, and the developmental status was assessed using Denver Developmental Screening Tests.ResultsA total of 48 BA children who received pLT at the age of 5.00 & PLUSMN; 0.94 months were analyzed. The weight-for-age Z-value (Z(W)) and length-for-age Z-value (Z(L)) were higher than the head circumference-for-age Z-value (Z(HC)) at pLT (P = 0.002 and 0.02), but they were all lower than the WHO growth standard (Z = 0) (P < 0.001). The Z(W) and Z(HC) decreased first and then returned to the population level at 1 year after pLT, while the Z(L) only returned to the preoperative status and was lower than the Z(W) and Z(HC) (P < 0.001). Developmental screening showed that 35% (17/48) of the children were defined as suspicious and 15% (7/48) were abnormal at 1-4 months after pLT, the most likely time to be suspected of developmental delay. At 1 year after pLT, gross motor skill delay still existed (12/45, 27%), and language skill delay began to appear (4/45, 9%).ConclusionsBA-pLT children suffer from growth and developmental problems. Low Z(HC) is the main growth problem before pLT, while low Z(L) is the problem after pLT. Developmental delays are significant after pLT, especially in motor and language skills. The current study suggested that further studies are warranted to clarify the long-term growth and developmental outcomes of BA-pLT children, to compare them with children undergoing the Kasai procedure and to explore their influencing factors and possible mechanisms."

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