Novel Effect of p-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets

作者全名："Yuan, Zhiyi; Lu, Xi; Lei, Fan; Sun, Hong; Jiang, Jingfei; Xing, Dongming; Du, Lijun"

作者地址："[Yuan, Zhiyi] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Lu, Xi; Lei, Fan; Jiang, Jingfei; Xing, Dongming; Du, Lijun] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China; [Lei, Fan; Jiang, Jingfei; Xing, Dongming; Du, Lijun] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China; [Sun, Hong] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant & Dev, Beijing 100094, Peoples R China"

通信作者："Du, LJ (通讯作者)，Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China.; Du, LJ (通讯作者)，Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China."

来源：MOLECULES

ESI学科分类：CHEMISTRY

WOS号：WOS:001017210100001

JCR分区：Q2

影响因子：4.2

年份：2023

卷号：28

期号：12

开始页：　

结束页：　

文献类型：Article

关键词：p-coumaric acid; hepatic lipase; lipid droplet; NAFLD; PPAR

摘要："p-coumaric acid (p-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of p-CA on the down-regulation of accumulated lipids in vivo and in vitro. p-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor & alpha;, and & gamma; (PPAR & alpha; and & gamma;). Furthermore, p-CA promoted adenosine 5 & PRIME;-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, p-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, p-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver."

基金机构："National Samp;T Major Special Project for New Drug Ramp;D Program of China [2012ZX09103-201-041]; National Natural Science Foundation of China [30801523]; Youth Fund of National Natural Science Foundation, China [81800389]; Chongqing Special Foundation for Postdoctoral Research Proposal, China [Xm2017021]; Program for Youth Innovation in Future Medicine, Chongqing Medical University, China [W0069]"

基金资助正文："We thank all the colleagues in our laboratory. This work was supported by National S & T Major Special Project for New Drug R & D Program of China (2012ZX09103-201-041), National Natural Science Foundation of China (30801523), Youth Fund of National Natural Science Foundation, China (No. 81800389), Chongqing Special Foundation for Postdoctoral Research Proposal, China (No. Xm2017021) and Program for Youth Innovation in Future Medicine, Chongqing Medical University, China (No. W0069). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript."